Cohen J M, Miller A, Spiera H
Chest. 1977 Oct;72(4):521-4. doi: 10.1378/chest.72.4.521.
A patient with classic rheumatoid arthritis developed biopsy-proven diffuse interstitial pulmonary fibrosis and ventilatory insufficiency which appeared to be irreversible. The administration of azathioprine coincided with significant immediate improvement in pulmonary function and clinical status. During five years of continuous azathioprine therapy, progressive improvement in lung function has been accompanied by marked deterioration of the rheumatoid joint disease, suggesting that the pulmonary and joint lesions of rheumatoid disease may not be mediated by the same pathways.
一名患有典型类风湿关节炎的患者出现了经活检证实的弥漫性间质性肺纤维化和通气功能不全，且似乎不可逆转。硫唑嘌呤的使用与肺功能和临床状况的显著即刻改善同时出现。在连续五年的硫唑嘌呤治疗期间，肺功能的逐步改善伴随着类风湿关节疾病的明显恶化，这表明类风湿疾病的肺部和关节病变可能并非由相同途径介导。
