砷的致癌、致畸和致突变作用。

Carcinogenic, teratogenic, and mutagenic effects of arsenic.

作者信息

Bencko V

出版信息

Environ Health Perspect. 1977 Aug;19:179-82. doi: 10.1289/ehp.7719179.

DOI:10.1289/ehp.7719179

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1637403/

Abstract

This review outlines briefly the history and present status of the problem of carcinogenic, teratogenic and mutagenic effects of arsenic. Discrepancies between clinical observations and positive results of epidemiological studies and the experimental induction of cancer by arsenic are discussed. The present knowledge of the mechanism of teratogenic and mutagenic effects of arsenic is analyzed. The growing importance of arsenic as an environmental pollutant is demonstrated. Continuation of throughly organized epidemiological studies in regions with excessive arsenic exposure of the population and standardization of an epidemiological approach to this problem on an international basis are recommended. New approaches in experimental studies of the carcinogenicity of arsenic in combination with other known or suspected carcinogens are recommended as well.

摘要

本综述简要概述了砷的致癌、致畸和致突变作用问题的历史和现状。讨论了临床观察结果与流行病学研究阳性结果之间的差异以及砷诱发癌症的实验情况。分析了目前对砷致畸和致突变作用机制的认识。证明了砷作为环境污染物的重要性日益增加。建议在人群砷暴露过量的地区继续开展全面组织的流行病学研究，并在国际范围内对该问题的流行病学方法进行标准化。还建议采用新方法对砷与其他已知或疑似致癌物联合致癌性进行实验研究。

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