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1
Carcinogenic, teratogenic, and mutagenic effects of arsenic.砷的致癌、致畸和致突变作用。
Environ Health Perspect. 1977 Aug;19:179-82. doi: 10.1289/ehp.7719179.
2
Carcinogenicity, teratogenicity and mutagenicity of arsenic.砷的致癌性、致畸性和致突变性。
Mutat Res. 1980 Jan;75(1):49-62. doi: 10.1016/0165-1110(80)90027-5.
3
Identification of carcinogenic, mutagenic and teratogenic substances in the environment.环境中致癌、致突变和致畸物质的鉴定。
Environ Qual Saf. 1975;4:200-25.
4
Mutagenicity, carcinogenicity and teratogenicity of antimony compounds.锑化合物的致突变性、致癌性和致畸性。
Mutat Res. 1996 Oct;366(1):1-8. doi: 10.1016/s0165-1110(96)90003-2.
5
Mutagenicity, carcinogenicity and teratogenicity of aluminium.铝的致突变性、致癌性和致畸性。
Mutat Res. 1988 Nov;196(3):247-57. doi: 10.1016/0165-1110(88)90009-7.
6
Comments on the carcinogenic, mutagenic, and teratogenic properties of anticancer drugs.关于抗癌药物致癌、致突变和致畸特性的评论。
Recent Results Cancer Res. 1980;74:306-11. doi: 10.1007/978-3-642-81488-4_37.
7
Carcinogenicity, mutagenicity and teratogenicity of nickel.镍的致癌性、致突变性和致畸性。
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8
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9
Carcinogenic, mutagenic, teratogenic workshop.致癌、致突变、致畸研讨会。
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Effects of Developmental Arsenic Exposure on the Social Behavior and Related Gene Expression in C3H Adult Male Mice.发育性砷暴露对成年雄性 C3H 小鼠社会行为及相关基因表达的影响。
Int J Environ Res Public Health. 2019 Jan 9;16(2):174. doi: 10.3390/ijerph16020174.
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4
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The effect of arsenic on urethan-induced adenoma formation in Swiss mice.砷对瑞士小鼠中乌拉坦诱导的腺瘤形成的影响。
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本文引用的文献

1
Cancer of skin and occupational trauma.皮肤癌与职业性创伤。
J Am Med Assoc. 1952 Jan 26;148(4):245-52. doi: 10.1001/jama.1952.02930040001001.
2
Arsenic and cancer; observations in the metallurgical industry.砷与癌症；冶金行业的观察结果
AMA Arch Ind Hyg Occup Med. 1951 Sep;4(3):199-205.
3
[CANCER MORTALITY IN ZONES OF ARSENICAL WATERS OF THE PROVINCE OF CORDOBA, ARGENTINE REPUBLIC. CONTRIBUTION TO THE REGIONAL PATHOLOGY OF CANCER].[阿根廷共和国科尔多瓦省含砷水域地区的癌症死亡率。对癌症区域病理学的贡献]
Prensa Med Argent. 1964 Oct 23;51:994-8.
4
EPIDEMIOLOGICAL CONSEQUENCES OF AN ARSENIC-LUNG CANCER THEORY.砷与肺癌理论的流行病学后果
Am J Public Health Nations Health. 1963 Aug;53(8):1229-32. doi: 10.2105/ajph.53.8.1229.
5
[Pulmonary cancer of arsenical origin in Beaujolais vineyeard workers].[博若莱葡萄园工人中砷源性肺癌]
J Fr Med Chir Thorac. 1963 Apr;17:303-11.
6
Neutron activation analysis of arsenic in normal skin, keratoses, and epitheliomas.正常皮肤、角化病和上皮瘤中砷的中子活化分析。
Arch Dermatol. 1959 Dec;80:672-7. doi: 10.1001/archderm.1959.01560240024003.
7
Multiple malignant and benign epidermal and dermal tumours following arsenic.砷暴露后出现的多种恶性和良性表皮及真皮肿瘤
Acta Derm Venereol. 1960;40:400-9.
8
Arsenical keratoses associated with carcinomas of the internal organs.与内脏癌相关的砷角化病
Can Med Assoc J. 1958 Mar 15;78(6):416-9.
9
[Arsenic, liver and tumors; hemangioendothelioma].[砷、肝脏与肿瘤；血管内皮瘤]
Z Krebsforsch. 1957;61(5):468-503.
10
[Chronic arsenic poisoning of Moselle vineyard-workers, with special reference to arsenic cancer].[摩泽尔葡萄园工人的慢性砷中毒，特别提及砷致癌]
Z Krebsforsch. 1956;61(3):287-319.

砷的致癌、致畸和致突变作用。

Carcinogenic, teratogenic, and mutagenic effects of arsenic.

作者信息

Bencko V

出版信息

Environ Health Perspect. 1977 Aug;19:179-82. doi: 10.1289/ehp.7719179.

DOI:10.1289/ehp.7719179
PMID:908296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1637403/
Abstract

This review outlines briefly the history and present status of the problem of carcinogenic, teratogenic and mutagenic effects of arsenic. Discrepancies between clinical observations and positive results of epidemiological studies and the experimental induction of cancer by arsenic are discussed. The present knowledge of the mechanism of teratogenic and mutagenic effects of arsenic is analyzed. The growing importance of arsenic as an environmental pollutant is demonstrated. Continuation of throughly organized epidemiological studies in regions with excessive arsenic exposure of the population and standardization of an epidemiological approach to this problem on an international basis are recommended. New approaches in experimental studies of the carcinogenicity of arsenic in combination with other known or suspected carcinogens are recommended as well.

摘要

本综述简要概述了砷的致癌、致畸和致突变作用问题的历史和现状。讨论了临床观察结果与流行病学研究阳性结果之间的差异以及砷诱发癌症的实验情况。分析了目前对砷致畸和致突变作用机制的认识。证明了砷作为环境污染物的重要性日益增加。建议在人群砷暴露过量的地区继续开展全面组织的流行病学研究，并在国际范围内对该问题的流行病学方法进行标准化。还建议采用新方法对砷与其他已知或疑似致癌物联合致癌性进行实验研究。