Nagakura Y, Sohda K, Ito H, Miyata K
Pharmacological Laboratories, Yamanouchi Pharmaceutical Co. Ltd., Ibaraki, Japan.
Eur J Pharmacol. 1997 Feb 19;321(1):53-7. doi: 10.1016/s0014-2999(97)00005-8.
Gastrointestinal motility was measured with force transducers in conscious ferrets. The gastrointestinal motility pattern in both the interdigestive and digestive states was similar to that reported for humans. The activity front, phase III contractions of the migrating motor complex, occurred cyclically in the antrum and migrated to the duodenum and ileum in the interdigestive state, and relatively low-amplitude contractions were sustained in the antrum, duodenum and ileum in the digestive state. Colonic motility was characterized by basal relatively low-amplitude contractions and a single high-amplitude contraction preceding defecation. Cisapride (0.3-3 mg/kg s.c.) enhanced antral and colonic motility. This ferret model will help the investigation and evaluation of drug effects on gastrointestinal motility in humans.
在清醒的雪貂身上使用力传感器测量胃肠动力。消化间期和消化期的胃肠动力模式与人类报道的相似。活动前沿，即移行性运动复合波的Ⅲ相收缩，在消化间期于胃窦部周期性出现，并向十二指肠和回肠迁移，而在消化期，胃窦、十二指肠和回肠持续出现相对低幅度的收缩。结肠动力的特征是基础状态下相对低幅度的收缩以及排便前单次高幅度的收缩。西沙必利（0.3 - 3毫克/千克，皮下注射）增强了胃窦和结肠的动力。这种雪貂模型将有助于研究和评估药物对人类胃肠动力的影响。
