Nagai T, Kanaya H, Matsushima K, Kamiyama S
Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
J Anal Toxicol. 1997 Mar-Apr;21(2):112-5. doi: 10.1093/jat/21.2.112.
The time-lapse changes of d- and i-forms in urine specimens collected in the 24 h after the oral dosing of two adult male subjects with 20 mg of racemic (dl)-ethylamphetamine (EAMP)-HCl were examined by high-performance liquid chromatography. The percentage of the excreted dose of nonmetabolized l-EAMP was larger than that of d-EAMP, and the percentage of the excreted dose of metabolized l-amphetamine (AMP) was smaller than that of d-AMP in both subjects, A and B. These differences were observed 4.5-24 h after administration of the drug. The changes in the l/d ratio of EAMP and AMP were not similar between subjects A and B, but the change in the total l/d ratio was nearly the same. The regression line for subject A was as follows: y = 0.021323x + 0.98399. The regression line for subject B was as follows: y = 0.020947x + 0.94893. These two regression lines suggested that the time lapsed after the administration to humans could be predicted. The total percent of the excreted doses of EAMP and AMP was 47.46% (the d-forms, 20.73%; the l-forms, 26.73%) for subject A and was 31.43% (the d-forms, 14.14%; the l-forms, 17.29%) for subject B. The l/d ratio was 1.29 for subject A and 1.22 for subject B, which was somewhat higher than that (1.01) of the dl-EAMP-HCl used.
通过高效液相色谱法检测了两名成年男性受试者口服20mg消旋（dl）-盐酸乙基苯丙胺（EAMP）后24小时内收集的尿液样本中d型和i型的延时变化。在受试者A和B中，未代谢的l-EAMP排泄剂量百分比均大于d-EAMP，而代谢的l-苯丙胺（AMP）排泄剂量百分比均小于d-AMP。这些差异在给药后4.5至24小时观察到。受试者A和B之间EAMP和AMP的l/d比值变化不相似，但总l/d比值变化几乎相同。受试者A的回归线如下：y = 0.021323x + 0.98399。受试者B的回归线如下：y = 0.020947x + 0.94893。这两条回归线表明给药后在人体内经过的时间可以预测。受试者A中EAMP和AMP排泄剂量的总百分比为47.46%（d型，20.73%；l型，26.73%），受试者B为31.43%（d型，14.14%；l型，17.29%）。受试者A的l/d比值为1.29，受试者B为1.22，略高于所用dl-EAMP-HCl的l/d比值（1.01）。
