Tei C, Nishimura R A, Seward J B, Tajik A J
Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota, USA.
J Am Soc Echocardiogr. 1997 Mar;10(2):169-78. doi: 10.1016/s0894-7317(97)70090-7.
A simple, reproducible, noninvasive Doppler index for the assessment of overall cardiac function has been described previously. The purpose of this study was to correlate the Doppler index with accepted indexes of cardiac catheterization of left ventricular performance. Thirty-four patients with ischemic heart disease or idiopathic dilated cardiomyopathy prospectively underwent a simultaneous cardiac catheterization and Doppler echocardiographic study. Invasive measurements of peak +dP/dt, peak -dP/dt, and tau were obtained from the high-fidelity left ventricular pressures. A Doppler index of myocardial performance was defined as the summation of isovolumetric contraction and relaxation time divided by ejection time. There was a correlation between Doppler measurement of isovolumetric contraction time and peak +dP/dt (r = 0.842; p < 0.0001) and Doppler measurement of isovolumetric relaxation time and peak -dP/dt (r = 0.638; p < 0.001). Left ventricular ejection time correlated with both peak +dP/dt (r = 0.539; p < 0.001) and peak -dP/dt (r = 0.582; p < 0.001). The Doppler index correlated with simultaneously recorded systolic peak +dP/dt (r = 0.821; p < 0.0001) and diastolic peak -dP/dt (r = 0.833; p < 0.001) and tau (r = 0.680; p < 0.0001). This study documents that a simple, easily recordable, noninvasive Doppler index of myocardial performance correlates with invasive measurement of left ventricular systolic and diastolic function and appears to be a promising noninvasive measurement of overall cardiac function.
此前已描述了一种用于评估整体心功能的简单、可重复、非侵入性的多普勒指数。本研究的目的是将该多普勒指数与公认的左心室功能心导管检查指数进行关联。34例缺血性心脏病或特发性扩张型心肌病患者前瞻性地同时接受了心导管检查和多普勒超声心动图研究。从高保真左心室压力中获得峰值 +dP/dt、峰值 -dP/dt 和 τ 的有创测量值。心肌性能的多普勒指数定义为等容收缩期和舒张期时间之和除以射血时间。等容收缩期时间的多普勒测量值与峰值 +dP/dt 之间存在相关性（r = 0.842；p < 0.0001），等容舒张期时间的多普勒测量值与峰值 -dP/dt 之间存在相关性（r = 0.638；p < 0.001）。左心室射血时间与峰值 +dP/dt（r = 0.539；p < 0.001）和峰值 -dP/dt（r = 0.582；p < 0.001）均相关。多普勒指数与同时记录的收缩期峰值 +dP/dt（r = 0.821；p < 0.0001）、舒张期峰值 -dP/dt（r = 0.833；p < 0.001）和 τ（r = 0.680；p < 0.0001）相关。本研究证明，一种简单、易于记录的非侵入性心肌性能多普勒指数与左心室收缩和舒张功能的有创测量值相关，似乎是一种有前景的整体心功能非侵入性测量方法。
