大鼠肾上腺切除术、卵巢人绒毛膜促性腺激素结合与雌性青春期的开始
Adrenalectomy, ovarian HCG-binding and the onset of female puberty in the rat.
作者信息
Siebers J W, Engel W
出版信息
Experientia. 1977 Oct 15;33(10):1394-6. doi: 10.1007/BF01920202.
PMID:908430
Abstract
The delay of puberty onset in female rats adrenalectomized before the 25th day of age is due neither to changes in the number of ovarian HCG-receptors nor to an altered hormone affinity of these receptors. It is assumed that glucocorticoids act on an intracellular level in the ovarian cells, possibly by alterations of cyclic AMP-dependent phosphodiesterase activity.
摘要
在25日龄前进行肾上腺切除的雌性大鼠青春期启动延迟，既不是由于卵巢HCG受体数量的变化，也不是由于这些受体的激素亲和力改变。据推测，糖皮质激素可能通过改变环磷酸腺苷依赖性磷酸二酯酶的活性，在卵巢细胞的细胞内水平发挥作用。
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