Meijs-Roelofs H M, Kramer P
J Endocrinol. 1977 Dec;75(3):419-26. doi: 10.1677/joe.0.0750419.
The involvement of the adrenal gland in the release of gonadotrophins and the onset of puberty in female rats was studied. Two and four days after adrenalectomy (ADX) on either day 5 or 10 after birth, a significant decrease in the concentration of FSH was found; 4 days after ADX on either day 15 or 20, FSH concentrations had increased significantly compared with sham-operated and/or intact controls. However, in the rats adrenalectomized on day 15 or 20, the body weights were lower than in control rats. Relative uterine weights (mg/100 g body wt) in adrenalectomized rats never differed from those of control rats. A delay in the time at which vaginal opening and the first oestrus occurred was found in rats adrenalectomized at 20 or 25 days of age; however this delay was accompanied in these rats by a retardation in the gain in body weight. It is argued that the effects of ADX on both the release of gonadotrophins and the onset of puberty are primarily, and presumably exclusively, due to the effects on general bodily development (expressed in body weight). The lack of effect of ADX on uterine weight supports the hypothesis that 'oestrogen-like' products from the adrenal gland are not biologically active as oestrogens.
研究了肾上腺在雌性大鼠促性腺激素释放及青春期启动过程中的作用。在出生后第5天或第10天进行肾上腺切除（ADX），术后2天和4天，促卵泡生成素（FSH）浓度显著降低；在出生后第15天或第20天进行ADX，术后4天，与假手术组和/或完整对照组相比，FSH浓度显著升高。然而，在出生后第15天或第20天进行肾上腺切除的大鼠中，体重低于对照大鼠。肾上腺切除大鼠的相对子宫重量（mg/100 g体重）与对照大鼠相比无差异。在20或25日龄时进行肾上腺切除的大鼠，阴道开口和首次发情时间延迟；然而，这些大鼠体重增加也延迟。有观点认为，ADX对促性腺激素释放和青春期启动的影响主要（可能也是唯一）是由于对整体身体发育（以体重表示）的影响。ADX对子宫重量无影响，支持了肾上腺产生的“雌激素样”产物在生物学上不具有雌激素活性这一假说。
