Nordgarden H, Jensen J L, Arneberg P, Storhaug K
TAKO-Centre, Oslo, Norway.
Spec Care Dentist. 1996 May-Jun;16(3):128-33. doi: 10.1111/j.1754-4505.1996.tb00846.x.
Complaints of dry mouth and poor dental health are common in persons with narcolepsy. The aim of this study was to investigate whether salivary secretion is reduced in narcolepsy. Persons using tricyclic anti-depressants (TCAs) were excluded, since TCAs are known to reduce salivary secretion. Thus, two patient subgroups were studied, one on central stimulant (CS) treatment (medicated group, n = 12), and one unmedicated group (n = 8), representing all persons with narcolepsy living in the Oslo area meeting these criteria. The survey group and 20 age- and sex-matched healthy control persons without symptoms of dry mouth were examined with respect to the following parameters: unstimulated (UWS) and chewing-stimulated (SWS) whole salivary flow rates, citric-acid-stimulated parotid and submandibular flow rates, buffering effect, and number of some aciduric micro-organisms in the oral cavity. As a group, persons with narcolepsy had lower whole salivary flow rates, a lower buffering effect, and higher Candida albicans scores than the control group. When the patients were divided into the medicated and unmedicated groups, these differences were valid only for the medicated group. Whether the observed differences were effects of CS medication or reflected that these persons were more seriously affected by the disease has to be further explored.
发作性睡病患者常主诉口干和牙齿健康不佳。本研究旨在调查发作性睡病患者的唾液分泌是否减少。使用三环类抗抑郁药（TCA）的患者被排除在外，因为已知TCA会减少唾液分泌。因此，研究了两个患者亚组，一组接受中枢兴奋剂（CS）治疗（用药组，n = 12），另一组为未用药组（n = 8），代表居住在奥斯陆地区符合这些标准的所有发作性睡病患者。对调查小组和20名年龄和性别匹配、无口干症状的健康对照者进行了以下参数检查：非刺激性（UWS）和咀嚼刺激性（SWS）全唾液流速、柠檬酸刺激的腮腺和颌下腺流速、缓冲作用以及口腔中一些耐酸微生物的数量。作为一个群体，发作性睡病患者的全唾液流速较低、缓冲作用较低，白色念珠菌评分高于对照组。当将患者分为用药组和未用药组时，这些差异仅在用药组中存在。观察到的差异是CS药物治疗的效果还是反映这些人受疾病影响更严重，还有待进一步探讨。
