Soules M R, Wiebe R H, Aksel S, Hammond C B
Fertil Steril. 1977 Oct;28(10):1033-7.
Between 1973 and 1975, 16 patients evaluated for infertility at Duke University Medical Center were diagnosed as having luteal phase deficiency. A majority had had prior infertility surveys, and the average duration of their infertility exceeded 2 years. The diagnosis was suspected after study of basal body temperature charts and menstrual patterns in more than 80% of the patients. This diagnosis was established by timed endometrial biopsy. The primary method of therapy was supplementation of the luteal phase with progesterone vaginal suppositories. The pregnancy rate after therapy was 50% and pregnancy occurred after a mean of five treatment cycles. The minimal follow-up of patients who failed to conceive was 8 months. To date, the majority of these pregnancies have been completed without complication and the remainder are progressing satisfactorily. Two additional patients developed luteal phase deficiency while taking clomiphene citrate and became pregnant with progesterone supplementation.
1973年至1975年间，在杜克大学医学中心接受不育症评估的16名患者被诊断为黄体期缺陷。大多数患者此前接受过不育症检查，其不育平均持续时间超过2年。超过80%的患者通过基础体温图和月经模式研究后怀疑有该诊断。通过定时子宫内膜活检确诊。主要治疗方法是用黄体酮阴道栓剂补充黄体期。治疗后的妊娠率为50%，平均经过五个治疗周期后怀孕。未受孕患者的最短随访时间为8个月。迄今为止，这些妊娠中的大多数已顺利完成，其余情况进展令人满意。另外两名患者在服用枸橼酸氯米芬时出现黄体期缺陷，补充黄体酮后怀孕。
