Chung P C, Sum D C, Wu R S
Department of Anesthesiology, Chang Gung Mem. Hospital, Kweishan, Taoyuan, Taiwan, R.O.C.
Acta Anaesthesiol Sin. 1996 Dec;34(4):235-8.
A case of intrahepatic metastatic pheochromocytoma with lymph nodes involvement undergoing resection of tumor was reported; intravenous labetalol in high dose regimen (2 mg/kg administered before skin incision) was used for blood pressure control during the operation. Marked sinus bradycardia was noted after receiving total dose of intravenous labetalol and treated [corrected] with intravenous atropine 0.4 mg. The total operation time was 6.5 h. We found that under isoflurane anesthesia, duration of action of intravenous labetalol was prolonged as adequate intraoperative blood pressure control was obtained throughout the 6-h surgical period without further need of supplementary medication. This finding suggested that duration of labetalol was extended when concomitantly used with isoflurane and the labetalol dosage in our regimen could be effectively used in surgical procedures lasting for more than 6 h.
报告了1例肝内转移性嗜铬细胞瘤伴淋巴结受累行肿瘤切除术的病例；术中采用大剂量静脉注射拉贝洛尔方案（皮肤切开前静脉注射2mg/kg）控制血压。静脉注射拉贝洛尔全量后出现明显窦性心动过缓，静脉注射0.4mg阿托品进行治疗[纠正]。总手术时间为6.5小时。我们发现，在异氟烷麻醉下，静脉注射拉贝洛尔的作用时间延长，因为在整个6小时手术期间均能充分控制术中血压，无需进一步补充用药。这一发现表明，拉贝洛尔与异氟烷合用时作用时间延长，我们方案中的拉贝洛尔剂量可有效用于持续时间超过6小时的手术。
