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[全甲状腺切除术在良性甲状腺疾病治疗中的作用]

[Role of total thyroidectomy in the treatment of benign thyroid diseases].

作者信息

Peix J L, Van Box Som P

机构信息

Service de Chirurgie Générale et Endocrinienne, Hôpital de l'Antiquaille, Lyon.

出版信息

Ann Endocrinol (Paris). 1996;57(6):502-7.

PMID:9084698
Abstract

In 1990, total thyroidectomy (T.T.) was performed in 4% of all benign thyroid diseases and in 7% in case of diffuse benign thyroid diseases, operated on in our surgical unit. In 1995, this incidence of T.T. increased to 20% and 37% respectively. Several considerations can explain this rise in T.T. indications. Currently, the incidence of reoperations on benign goiters represents 4.5% of all our thyroid surgery. It can be considered as a failure of a first incomplete operation. Furthermore, most of goiter recurrences are medically treated and the recurrence rate is higher than the reoperation rate. In Grave's disease, surgery is indicated after medical treatment failure or for acute complications. In this case, the aim of surgery is radical cure of hyperthyroidism. Because evaluation of the weight of thyroid remnant for prevention of postoperative hypothyroidism is difficult, indication of T.T. with thyroxin replacement therapy can be proposed. Surgical excision of a multinodular goiter is indicated for large size lesions, tracheal compression or thyrotoxic evolution. Over the years subtotal thyroidectomy was performed for these benign lesions. Subtotal thyroidectomy leaves a diseased remnant gland. Attempts to suppress nodular recurrence by thyroxin treatment do not guarantee success. Then T.T. can be advocated since postoperative thyroxin therapy is often given after subtotal thyroidectomy to prevent hypothyroidism. Total thyroidectomy is an appropriate operation for the management of a benign thyroid disease because it precludes patients from requiring further surgery for recurrent diseases. However, it requires two conditions. In first, the patient must have the psychologic and economic capacity for a permanent medical therapy. The other is that the procedure be performed with low risks of complications in comparison with subtotal thyroidectomies. Currently recurrential palsy and hypoparathyroidism rates are evaluated in the literature between 0 and 3%.

摘要

1990年,在我们外科病房接受手术的所有良性甲状腺疾病患者中,4%接受了全甲状腺切除术(T.T.);弥漫性良性甲状腺疾病患者中,这一比例为7%。1995年,全甲状腺切除术的发生率分别升至20%和37%。有几个因素可以解释全甲状腺切除术指征的增加。目前,良性甲状腺肿再次手术的发生率占我们所有甲状腺手术的4.5%。这可被视为首次不完全手术的失败。此外,大多数甲状腺肿复发采用药物治疗,复发率高于再次手术率。在格雷夫斯病中,药物治疗失败或出现急性并发症时需进行手术。在这种情况下,手术的目的是根治甲亢。由于难以评估甲状腺残留量以预防术后甲状腺功能减退,因此可考虑采用全甲状腺切除术并辅以甲状腺素替代治疗。对于大尺寸病变、气管受压或甲状腺毒症进展的多结节性甲状腺肿,建议进行手术切除。多年来,对于这些良性病变均施行次全甲状腺切除术。次全甲状腺切除术会留下病变的残余腺体。试图通过甲状腺素治疗抑制结节复发并不能保证成功。由于次全甲状腺切除术后通常会给予甲状腺素治疗以预防甲状腺功能减退,因此可提倡全甲状腺切除术。全甲状腺切除术是治疗良性甲状腺疾病的一种合适手术方式,因为它可避免患者因疾病复发而需要再次手术。然而,这需要两个条件。其一,患者必须有心理和经济能力接受长期药物治疗。其二,与次全甲状腺切除术相比,该手术的并发症风险较低。目前,文献报道的喉返神经麻痹和甲状旁腺功能减退发生率在0%至3%之间。

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