Cohn R C, Rudzienski L
Department of Pediatrics, Wright State University, Dayton, Ohio, USA.
Chemotherapy. 1997 Mar-Apr;43(2):100-7. doi: 10.1159/000239543.
Antibiotic-resistant Burkholderia cepacia is an important pathogen in cystic fibrosis. We have previously shown enhanced tobramycin susceptibility of most strains in the presence of the drug amiloride. Others have shown similar findings in the presence of cationic agents with amine groups. To examine the relationship of substituted amine drug structure and synergy potential with tobramycin, the in vitro activity of 45 non-antibiotic substituted amine and related compounds in the presence and absence of tobramycin was studied. Very few agents had intrinsic antimicrobial action but many were very synergistic with tobramycin. Dichloroisoproterenol and propranolol were the most synergistic. Sympathomimetic, imidazoline agents, phenothiazenes, and thioxanthenes varied greatly. Exploration of these compounds may provide an avenue for treating antibiotic-resistant B. cepacia.
耐抗生素的洋葱伯克霍尔德菌是囊性纤维化中的一种重要病原体。我们之前已经表明，在存在阿米洛利药物的情况下，大多数菌株对妥布霉素的敏感性增强。其他人在存在含胺基团的阳离子剂的情况下也有类似的发现。为了研究取代胺药物结构与与妥布霉素的协同潜力之间的关系，研究了45种非抗生素取代胺及相关化合物在有和没有妥布霉素存在时的体外活性。很少有药物具有内在抗菌作用，但许多药物与妥布霉素具有很强的协同作用。二氯异丙肾上腺素和普萘洛尔的协同作用最强。拟交感神经药、咪唑啉剂、吩噻嗪类和噻吨类药物的协同作用差异很大。对这些化合物的探索可能为治疗耐抗生素的洋葱伯克霍尔德菌提供一条途径。
