Baynes K C, Boucher B J, Feskens E J, Kromhout D
Cellular Mechanisms Research Group, St. Bartholomew's, Royal London School of Medicine and Dentistry, Whitechapel, London, UK.
Diabetologia. 1997 Mar;40(3):344-7. doi: 10.1007/s001250050685.
Vitamin D status was assessed in 142 elderly Dutchmen participating in a prospective population-based study of environmental factors in the aetiology of non-insulin-dependent diabetes mellitus. Of the men aged 70-88 years examined between March and May 1990, 39% were vitamin D depleted. After adjustment for confounding by age, BMI, physical activity, month of sampling, cigarette smoking and alcohol intake the 1-h glucose and area under the glucose curve during a standard 75-g oral glucose tolerance test (OGTT) were inversely associated with the serum concentration of 25-OH vitamin D (r = -0.23, p < 0.01; r = -0.26, p < 0.01, respectively). After excluding newly diagnosed diabetic patients total insulin concentrations during OGTT were also inversely associated with the concentration of 25-OH vitamin D (r = -0.18 to -0.23, p < 0.05). Hypovitaminosis D may be a significant risk factor for glucose intolerance.
对142名参与非胰岛素依赖型糖尿病病因环境因素前瞻性人群研究的荷兰老年男性进行了维生素D状况评估。在1990年3月至5月间检查的70 - 88岁男性中，39%存在维生素D缺乏。在对年龄、体重指数、身体活动、采样月份、吸烟和饮酒等混杂因素进行调整后，标准75克口服葡萄糖耐量试验（OGTT）期间的1小时血糖和血糖曲线下面积与25 - OH维生素D的血清浓度呈负相关（r = -0.23，p < 0.01；r = -0.26，p < 0.01）。排除新诊断的糖尿病患者后，OGTT期间的总胰岛素浓度也与25 - OH维生素D的浓度呈负相关（r = -0.18至 -0.23，p < 0.05）。维生素D缺乏可能是葡萄糖不耐受的一个重要危险因素。
