Nagano K, Katagiri T, Aiso S, Senoh H, Sakura Y, Takeuchi T
Japan Bioassay Research Center, Division of Pathology, Kanagawa, Japan.
Exp Toxicol Pathol. 1997 Feb;49(1-2):97-104. doi: 10.1016/S0940-2993(97)80077-2.
The outline of spontaneous lesions of the nasal cavity that were commonly observed in F344 rats and BDF1 mice used as untreated control groups in ten 2-year carcinogenicity studies were presented. In rats, the common spontaneous lesions were eosinophilic change of the respiratory epithelium and the olfactory epithelium, respiratory metaplasia of glands and the olfactory epithelium, foreign body inflammation, deposit of calcium, and thrombus. In mice, the common spontaneous lesions were eosinophilic change of the respiratory epithelium and olfactory epithelium, and respiratory metaplasia of glands and the olfactory epithelium. Some of these lesions revealed either species or sex-related differences of incidence.
介绍了在十项为期两年的致癌性研究中用作未处理对照组的F344大鼠和BDF1小鼠鼻腔常见的自发性病变概况。在大鼠中，常见的自发性病变为呼吸道上皮和嗅上皮的嗜酸性改变、腺体和嗅上皮的呼吸道化生、异物炎症、钙沉积和血栓。在小鼠中，常见的自发性病变为呼吸道上皮和嗅上皮的嗜酸性改变，以及腺体和嗅上皮的呼吸道化生。其中一些病变在发病率上显示出种属或性别差异。
