Anastasiadis P, Anninos P, Adamopoulos A, Sivridis E
Department of Obstetrics and Gynecology, Democritus University of Thrace and General Hospital, Alexandroupolis, Greece.
J Perinat Med. 1997;25(1):35-42. doi: 10.1515/jpme.1997.25.1.35.
This study was set to investigate the hemodynamics of the feto-placental circulation in normal and pre-ecclamptic pregnancies using the biomagnetometer SQUID. Thirteen women with pre-eclampsia and 26 healthy women were studied. All were "near term". Biomagnetic signals (waveforms) were recorded from the umbilical arteries. After statistical Fourier analysis, the findings were assigned arbitrarily in terms of spectral amplitudes as high (200-300 fT/ root of Hz), low (80-150 fT/ root of Hz) and borderline (151-199 fT/ root of Hz). In all cases the frequencies considered were distributed in the range 2-7 Hz. Interestingly, the umbilical artery waveforms and the corresponding spectral densities were of high amplitudes in most (88%) normal pregnancies of low amplitudes in most (84.6%) pregnancies complicated with pre-eclampsia. These findings were of statistical significance and were correlated with fetal heart rate (FHR) monitoring, pH and Apgar score at 1 and 5 minutes; high amplitude cases were related with normal FHR monitoring, pH > 7.25 and Apgar score > 7, while low amplitude recordings were connected with abnormal FHR patterns, pH < 7.25 and Apgar score < 7. It is suggested that biomagnetic measurements of the umbilical artery flow, which is an entirely new application of SQUID technology, is a promising procedure in assessing fetal health, especially in high risk pregnancies.
本研究旨在使用生物磁强计超导量子干涉仪（SQUID），调查正常妊娠和先兆子痫妊娠中胎儿 - 胎盘循环的血流动力学。研究了13名先兆子痫妇女和26名健康妇女。所有研究对象均“接近足月”。从脐动脉记录生物磁信号（波形）。经过统计傅里叶分析后，根据频谱幅度将结果任意分为高（200 - 300 fT/Hz平方根）、低（80 - 150 fT/Hz平方根）和临界（151 - 199 fT/Hz平方根）。在所有情况下，所考虑的频率分布在2 - 7Hz范围内。有趣的是，在大多数（88%）正常妊娠中，脐动脉波形和相应的频谱密度为高幅度，而在大多数（84.6%）合并先兆子痫的妊娠中为低幅度。这些发现具有统计学意义，并与胎儿心率（FHR）监测、1分钟和5分钟时的pH值及阿氏评分相关；高幅度情况与正常FHR监测、pH>7.25和阿氏评分>7相关，而低幅度记录与异常FHR模式、pH<7.25和阿氏评分<7相关。有人提出，脐动脉血流的生物磁测量作为SQUID技术的全新应用，在评估胎儿健康方面是一种有前景的方法，尤其是在高危妊娠中。
