Kulier R, Gülmezoĝlu A M, Hofmeyr G J, Van Gelderen C J
Department of Obstetrics and Gynecology, Coronation/JG Strijdom, Johannesburg, South Africa.
J Perinat Med. 1997;25(1):97-100. doi: 10.1515/jpme.1997.25.1.97.
The objective of the study was to investigate if a single dose of Hexoprenaline administered to patients diagnosed as having fetal distress improves neonatal outcome and whether there are any side effects and complications related to hexoprenaline injection. Patients with fetal distress diagnosed by electronic fetal heart rate monitoring with a gestational age of 35 weeks or more in active labor were eligible. Once the decision to deliver the patient by Cesarean section was made, patients were approached and randomised by sealed opaque envelopes to hexoprenaline or control groups. Ten micrograms of hexoprenaline were administered intravenously to study patients. Main outcomes were cord blood gas values, Apgar scores, the need for resuscitation and admission to intensive care. There were no statistically significant differences in the main outcome measures between the two groups. Fewer babies in the hexoprenaline group had a pH of < 7.2 and a base excess of < -10, but this was not statistically significant. The fetal heart rate pattern was improved in significantly more patients after hexoprenaline administration than controls. In conclusion, despite the statistically significant improvement in fetal heart rate tracings, Apgar scores and blood gas values showed only a trend towards improvement in the hexoprenaline group.
该研究的目的是调查给被诊断为胎儿窘迫的患者单次注射海索那林是否能改善新生儿结局，以及海索那林注射是否存在任何副作用和并发症。符合条件的患者为在活跃期经电子胎儿心率监测诊断为胎儿窘迫、孕周35周及以上的产妇。一旦决定对患者进行剖宫产，就会联系患者，并通过密封不透明信封将其随机分为海索那林组或对照组。给研究组患者静脉注射10微克海索那林。主要结局指标为脐血气值、阿氏评分、复苏需求及重症监护病房收治情况。两组间主要结局指标无统计学显著差异。海索那林组pH值<7.2且碱剩余<-10的婴儿较少，但无统计学显著性。与对照组相比，注射海索那林后胎儿心率模式改善的患者明显更多。总之，尽管胎儿心率描记图有统计学显著改善，但海索那林组的阿氏评分和血气值仅显示出改善趋势。
