Romano P R, Caton J G, Puzas J E
Department of Orthopaedics, University of Rochester School of Medicine, NY 14642, USA.
J Periodontal Res. 1997 Jan;32(1 Pt 2):143-7. doi: 10.1111/j.1600-0765.1997.tb01396.x.
The reversal line demarcates the cessation of osteoclast activity from the commencement of osteoblast activity at a remodeling site in bone. It is a seam between segments of bone that are formed at different times. We believe that the reversal line contains regulatory signals that, in part, control osteoblast activity. We have conducted a pilot study to examine the fate of reversal lines during abnormal bone remodeling in alveolar bone. A surgical periodontal defect was created in a Cynomolgus monkey (Macaca fascicularis), allowed to heal in the presence of plaque, and evaluated histologically. In this model, there is an acute inflammatory reaction followed by compromised bone formation. Woven bone rather than lamellar bone was deposited in the defect. A striking finding in this wound-healing model was the disruption of the carbohydrate material along the reversal line. This supports our theory that disruption of the signaling molecules in the reversal line may be responsible for uneven woven bone formation.
反转线界定了骨重塑部位破骨细胞活动的停止与成骨细胞活动的开始。它是在不同时间形成的骨段之间的一条缝。我们认为反转线包含部分控制成骨细胞活动的调节信号。我们进行了一项初步研究，以检查牙槽骨异常骨重塑过程中反转线的命运。在一只食蟹猴（猕猴）身上制造了一个牙周手术缺损，使其在有菌斑的情况下愈合，并进行组织学评估。在这个模型中，会有急性炎症反应，随后骨形成受损。缺损处沉积的是编织骨而非板层骨。在这个伤口愈合模型中一个显著的发现是沿反转线的碳水化合物物质受到破坏。这支持了我们的理论，即反转线中信号分子的破坏可能是编织骨形成不均匀的原因。
