Pant B, Arita K, Kurisu K, Tominaga A, Eguchi K, Uozumi T
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Neurosurg Rev. 1997;20(1):13-7. doi: 10.1007/BF01390519.
The incidence of intracranial aneurysm associated with pituitary adenoma is not definitely established although reported higher than in general population. This study was designed to find the existence of such association in a large series of pituitary adenoma cases. A retrospective study of 467 cases of pituitary adenoma (mean age: 41 +/- 15 years) was done. All patients underwent cerebral angiography at least of anterior circulation, detailed hormonal study, and 155 cases had additional magnetic resonance (MR) angiography. Twenty-five cases (5.4%) of pituitary adenoma (mean age 52 years) had intracranial aneurysm, 97% on anterior circulation, and 12% had multiple aneurysms. Two cases presented with aneurysmal rupture and the rest were incidental. Aneurysm was more frequently seen with increasing age (p < 0.001) and the age distribution resembled that of aneurysm among general population. Although the combination was most frequent among nonfunctioning adenoma (8.8%), and least frequent among prolactinoma (2.4%), this association was again due to age factor. There was no association between hormone secretion, size and invasive nature of the tumor. The results showed no association between intracranial aneurysm and pituitary adenoma. Our speculation is that such occurrence is merely a chance factor and the risk is no greater than that among general population.
虽然有报道称垂体腺瘤伴发颅内动脉瘤的发生率高于普通人群，但该发生率尚未明确确定。本研究旨在在大量垂体腺瘤病例中探寻这种关联的存在。对467例垂体腺瘤患者（平均年龄：41±15岁）进行了一项回顾性研究。所有患者至少接受了前循环的脑血管造影、详细的激素研究，155例患者还接受了磁共振（MR）血管造影。25例（5.4%）垂体腺瘤患者（平均年龄52岁）患有颅内动脉瘤，97%位于前循环，12%为多发动脉瘤。2例患者出现动脉瘤破裂，其余为偶然发现。动脉瘤在年龄增长时更常见（p<0.001），其年龄分布与普通人群中动脉瘤的年龄分布相似。虽然这种合并在无功能腺瘤中最为常见（8.8%），在泌乳素瘤中最少见（2.4%），但这种关联同样是由年龄因素导致的。肿瘤的激素分泌、大小和侵袭性之间没有关联。结果显示颅内动脉瘤与垂体腺瘤之间没有关联。我们推测这种情况仅仅是一个偶然因素，其风险并不高于普通人群。
