Agmo A, Soria P
Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Tours, France.
Psychopharmacology (Berl). 1997 Feb;129(4):372-81. doi: 10.1007/s002130050203.
Female rats were allowed to pace sexual interactions in a bilevel chamber, where a sexually vigorous male was tethered to the bottom level. Exploratory behaviors (sniffing, rearing), locomotor activity (expressed as number of level changes and periods of inactivity) as well as items of sexual motivation (latency to descend to the male's level, approaches towards the male and genital exploration) were recorded. In addition, sexual receptivity was evaluated in a non-paced situation. A test for motor impairment was also performed. The GABA transaminase inhibitor gamma-acetylene GABA reduced exploratory behaviors at doses much lower than those needed to reduce receptivity. The GABA reuptake inhibitor SKF 100330A did not affect any behavior category at doses of 15 and 30 mg/kg, but had a sedative action at 60 mg/kg. This was shown as impaired motor coordination and an almost total absence of activity in the bilevel chamber. Receptivity was not impaired, however. The mixed GABAA/ GABAB agonist progabide reduced exploratory behaviors and receptivity without producing motor impairment at a dose of 400 mg/kg. The GABAA agonist THIP impaired motor coordination and reduced receptivity and exploratory behaviors at a dose of 10 mg/kg. A larger dose, 20 mg/kg, had a strong sedative action. Only a small proportion of the animals descended to the males level. The GABAB agonist baclofen reduced receptivity at a dose that had no effect on motor coordination or exploratory behaviors. None of the drugs had a specific effect on sexual motivation. Whenever behaviors reflecting motivation were reduced, there were also other behavioral effects indicative of sedation. These data show that GABA receptor agonists, particularly the GABAB agonist baclofen, reduce sexual receptivity at doses that have only slight effect on motor functions or exploratory behaviors. In contrast, non-specific enhancement of GABAergic activity by a transaminase or reuptake inhibitor have effects on motor functions and exploratory behaviors at doses much lower than those needed to reduce receptivity.
将雌性大鼠置于双层箱中进行性行为实验，雄性大鼠精力充沛且被拴在下层。记录探索行为（嗅探、直立）、运动活动（以层数变化次数和静止时间表示）以及性动机行为（下降至雄性所在层的潜伏期、接近雄性和生殖器探索）。此外，在无节奏的情况下评估性接受能力。还进行了运动障碍测试。GABA转氨酶抑制剂γ-乙炔基GABA在远低于降低性接受能力所需的剂量下就能减少探索行为。GABA再摄取抑制剂SKF 100330A在15和30mg/kg剂量时对任何行为类别均无影响，但在60mg/kg时有镇静作用，表现为运动协调性受损以及在双层箱中几乎完全没有活动。然而，性接受能力并未受损。GABAA/GABAB混合激动剂普罗加比在400mg/kg剂量时减少探索行为和性接受能力，且不产生运动障碍。GABAA激动剂THIP在10mg/kg剂量时损害运动协调性，降低性接受能力和探索行为。20mg/kg的较大剂量有强烈的镇静作用，只有一小部分动物下降至雄性所在层。GABAB激动剂巴氯芬在对运动协调性或探索行为无影响的剂量下降低性接受能力。这些药物均对性动机无特异性作用。每当反映动机的行为减少时，也会有其他表明镇静的行为效应。这些数据表明，GABA受体激动剂，特别是GABAB激动剂巴氯芬，在对运动功能或探索行为仅有轻微影响的剂量下就能降低性接受能力。相比之下，转氨酶或再摄取抑制剂对GABA能活性的非特异性增强在远低于降低性接受能力所需的剂量时就会对运动功能和探索行为产生影响。
