Paredes R G, Contreras J L, Agmo A
Escuela de Psicología, Universidad Anáhuac, Mexico City, Mexico.
J Psychopharmacol. 1998;12(2):186-91. doi: 10.1177/026988119801200211.
The effects of gamma-amino butyric acid (GABA)-ergic drugs on male rabbit sexual behaviour have been evaluated. The GABA(A) agonist 4,5,6,7-tetrahydroxixazolo-5,4c-pyridin-3-ol (THIP), the GABA(B) agonist R-baclofen and the GABA antagonists picrotoxin and bicuculline were used. Injection of THIP, 20 mg/kg, s.c. produced a complete suppression of sexual behaviour and R-baclofen, 2.5 mg/kg, s.c. a significant inhibition. Intraperitoneal injections produced effects at higher doses than did s.c. injections. The inhibition produced by R-baclofen was associated with strong motor effects as shown by the water escape test. It is probable, therefore, that the reduced sexual behaviour observed after treatment with this drug is a consequence of sedative or muscle relaxant effects. By contrast, the dose of THIP that inhibited sexual behaviour had no effect on the water escape test. These results show that the GABA(A) agonist inhibits sexual behaviour in the male rabbit independent of effects on the motor system. The GABA antagonists had marginal or no effects on sexual behaviour. When these data are compared to previous results in the rat, substantial differences are seen. As there are differences between the effects on rat and rabbit sexual behaviour by other types of drugs, it appears that drug action on sexual behaviour cannot be generalized from one species to another.
已评估了γ-氨基丁酸（GABA）能药物对雄性兔性行为的影响。使用了GABA(A)激动剂4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇（THIP）、GABA(B)激动剂R-巴氯芬以及GABA拮抗剂印防己毒素和荷包牡丹碱。皮下注射20mg/kg的THIP可完全抑制性行为，皮下注射2.5mg/kg的R-巴氯芬则产生显著抑制作用。腹腔注射产生作用的剂量高于皮下注射。如在水逃避试验中所示，R-巴氯芬产生的抑制作用与强烈的运动效应相关。因此，很可能在用这种药物治疗后观察到的性行为减少是镇静或肌肉松弛作用的结果。相比之下，抑制性行为的THIP剂量对水逃避试验没有影响。这些结果表明，GABA(A)激动剂在雄性兔中抑制性行为，且与对运动系统的影响无关。GABA拮抗剂对性行为的影响很小或没有影响。当将这些数据与之前在大鼠中的结果进行比较时，可发现明显差异。由于其他类型药物对大鼠和兔性行为的影响存在差异，似乎药物对性行为的作用不能从一个物种推广到另一个物种。
