Shoji T, Tadano T, Kisara K
Nihon Yakurigaku Zasshi. 1977 May;73(4):371-8.
The present experiments were undertaken in investigate the effects of Ro4-4602 plus L-Dopa on biphasic action induced by metaraminol (MA) in mice. The following results were obtained: Spontaneous motor activity (SMA) suppressed by MA was recovered by pretreatment of Ro4-4602 plus L-Dopa and increased by more than 100 mg/kg of L-Dopa. However, SMA was increased by more than 400 mg/kg of L-Dopa in saline pretreated mice. In MA pretreated mice, SMA by L-Dopa markedly increased in proportion to the doses of MA. The peak time of SMA by L-Dopa in MA pretreated mice was observed to be faster than that in saline pretreated mice. When L-Dopa was injected into MA and saline pretreated mice, there was no significant difference of brain dopamine content between the two groups. From the above results, it is considered that the enhanced effect of L-Dopa in MA pretreated mice may be due to production of a supersensitivity to catecholamines in the central nervous system. MA induced hyper-motor activity was enhanced by pretreatment of Ro4-4602 plus L-Dopa which have no influence on SMA.
进行本实验以研究Ro4-4602加左旋多巴对间羟胺（MA）诱导的小鼠双相作用的影响。获得以下结果：MA抑制的自发运动活动（SMA）通过Ro4-4602加左旋多巴预处理得以恢复，且左旋多巴剂量超过100mg/kg时活动增加。然而，在生理盐水预处理的小鼠中，左旋多巴剂量超过400mg/kg时SMA增加。在MA预处理的小鼠中，左旋多巴诱导的SMA与MA剂量成比例显著增加。观察到MA预处理小鼠中左旋多巴诱导的SMA峰值时间比生理盐水预处理小鼠更快。当向MA和生理盐水预处理的小鼠注射左旋多巴时，两组之间脑多巴胺含量无显著差异。从上述结果来看，认为左旋多巴在MA预处理小鼠中的增强作用可能是由于中枢神经系统对儿茶酚胺产生了超敏反应。MA诱导的运动亢进通过Ro4-4602加左旋多巴预处理得以增强，而这对SMA无影响。
