一种核糖核酸酶MRP和核糖核酸酶P共有的新型蛋白质。
A novel protein shared by RNase MRP and RNase P.
作者信息
Chu S, Zengel J M, Lindahl L
机构信息
Department of Biological Sciences, UMBC-University of Maryland Baltimore County, 21250, USA.
出版信息
RNA. 1997 Apr;3(4):382-91.
Abstract
We have isolated suppressors of the temperature-sensitive rRNA processing mutation rrp2-2 in Saccharomyces cerevisiae. A class of extragenic suppressors was mapped to the YBR257w reading frame in the right arm of Chromosome II. Characterization of this gene, renamed POP4, shows that the gene product is necessary both for normal 5.8S rRNA processing and for processing of tRNA. Immunoprecipitation studies indicate that Pop4p is associated with both RNase MRP and RNase P. The protein is also required for accumulation of RNA from each of the two ribonucleoprotein particles.
摘要
我们已经在酿酒酵母中分离出了温度敏感型rRNA加工突变rrp2-2的抑制子。一类基因外抑制子被定位到了第二条染色体右臂上的YBR257w阅读框。对这个重新命名为POP4的基因的特性分析表明，该基因产物对于正常的5.8S rRNA加工和tRNA加工都是必需的。免疫沉淀研究表明，Pop4p与核糖核酸酶MRP和核糖核酸酶P都有关联。该蛋白质对于这两种核糖核蛋白颗粒中每种颗粒的RNA积累也是必需的。
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