Fridström M, Akerlöf E, Sjöblom P, Hillensjö T
Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden.
Gynecol Endocrinol. 1997 Feb;11(1):25-8. doi: 10.3109/09513599709152313.
We were interested in the degree of downregulation in women with poor response to in vitro fertilization (IVF) treatment. Ten women who were poor-responders, arbitrarily defined as having fewer than three follicles with diameter > 14 mm on days 9 and 10 of urofollitropin therapy, were compared with ten women who were not poor-responders, in a standard IVF program. The serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol after pituitary down-regulation did not differ between the two groups. The daily dose and the serum level of FSH were higher in poor-responders and there was a significant correlation between the dose of urofollitropin and the serum FSH level. There was no difference in serum LH level during ovulation stimulation between the groups. The clinical pregnancy rate was similar in the two groups although fewer embryos were transferred in the poor-response group. In conclusion, there was no difference with regard to pituitary suppression in normal-responders and poor-responders.
我们关注体外受精（IVF）治疗反应不佳的女性的下调程度。在一个标准的IVF程序中，将10名反应不佳的女性（被任意定义为在尿促卵泡素治疗第9天和第10天直径大于14mm的卵泡少于3个）与10名非反应不佳的女性进行比较。垂体下调后两组的促卵泡激素（FSH）、促黄体生成素（LH）和雌二醇的血清水平没有差异。反应不佳者的FSH每日剂量和血清水平较高，且尿促卵泡素剂量与血清FSH水平之间存在显著相关性。两组在排卵刺激期间的血清LH水平没有差异。尽管反应不佳组移植的胚胎较少，但两组的临床妊娠率相似。总之，正常反应者和反应不佳者在垂体抑制方面没有差异。
