Artini P G, Fasciani A, Cela V, Battaglia C, de Micheroux A A, D'Ambrogio G, Genazzani A R
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Gynecol Endocrinol. 1997 Feb;11(1):59-68. doi: 10.3109/09513599709152318.
Recent case reports of ovarian cancer associated with infertility treatment raise the question of a possible etiopathogenetic role of fertility drugs in ovarian cancer. In this paper, the possible relationship between infertility treatment and ovarian cancer is reviewed with respect to the epidemiological and pathogenetic profiles of ovarian cancer and the potential risk factors associated with fertility drugs; a case report review and a critical reappraisal are also provided within this article. Currently available data in the literature, from epidemiological studies and case reports, suggest that a direct causal effect of infertility treatment on ovarian cancer seems unlikely. Since infertile women are likely to have a higher risk for the development of ovarian cancer, and the role of fertility drugs in the etiopathogenesis of ovarian carcinoma is not established, a close clinical examination of infertile patients before, during and after infertility treatment is recommended. Moreover, further investigation is required to resolve the question of the possible association between fertility drugs and ovarian cancer through large prospective epidemiological or retrospective case-control studies.
近期关于卵巢癌与不孕症治疗相关的病例报告引发了生育药物在卵巢癌病因发病机制中可能作用的问题。本文就卵巢癌的流行病学和发病机制概况以及与生育药物相关的潜在风险因素，对不孕症治疗与卵巢癌之间的可能关系进行了综述；本文还提供了病例报告回顾和批判性重新评估。文献中目前可得的数据，来自流行病学研究和病例报告，表明不孕症治疗对卵巢癌有直接因果效应似乎不太可能。由于不孕女性患卵巢癌的风险可能更高，且生育药物在卵巢癌病因发病机制中的作用尚未明确，建议在不孕症治疗前、治疗期间和治疗后对不孕患者进行密切的临床检查。此外，需要通过大型前瞻性流行病学或回顾性病例对照研究进一步调查，以解决生育药物与卵巢癌之间可能关联的问题。
