Mosgaard B J, Lidegaard O, Kjaer S K, Schou G, Andersen A N
University of Copenhagen, and Institute of Cancer Epidemiology, Danish Cancer Society.
Fertil Steril. 1998 Dec;70(6):1049-55. doi: 10.1016/s0015-0282(98)00337-9.
To assess the risk of borderline ovarian cancer among infertile women treated with fertility drugs.
Case-control study.
Nationwide data obtained from public registers and postal questionnaires.
PATIENT(S): All Danish women <60 years old with borderline ovarian cancer during the period 1989-1994 and randomly selected population controls. The analysis included 231 cases and 1,721 controls.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Influence of parity, infertility, and fertility drugs on the risk of borderline ovarian cancer after multivariate confounder control.
RESULT(S): The odds ratio (OR) for borderline ovarian cancer among infertile untreated nulliparous women compared with fertile nulliparous women was 1.9. The OR for borderline ovarian cancer among treated nulliparous women compared with untreated infertile nulliparous women was 1.5, and the OR among treated parous women compared with untreated infertile parous women was 1.5.
CONCLUSION(S): Among fertile women, the difference in the risk of borderline ovarian cancer between nulliparous women and parous women was not statistically significant. Nulliparous women who were infertile and who did not receive medical treatment had a twofold higher risk of borderline ovarian cancer than fertile nulliparous women. There was no statistically significant increase in the risk of borderline ovarian cancer among nulliparous women who were treated with fertility drugs compared with nulliparous untreated infertile women or among parous women who were treated with fertility drugs compared with parous untreated infertile women.
评估接受生育药物治疗的不孕女性发生卵巢交界性肿瘤的风险。
病例对照研究。
从公共登记处和邮政调查问卷获得的全国性数据。
1989年至1994年期间所有年龄小于60岁的丹麦卵巢交界性肿瘤女性患者以及随机选择的人群对照。分析纳入231例病例和1721例对照。
无。
在多变量混杂因素控制后，产次、不孕和生育药物对卵巢交界性肿瘤风险的影响。
未接受治疗的不孕未育女性与已育未育女性相比，卵巢交界性肿瘤的比值比（OR）为1.9。接受治疗的未育女性与未接受治疗的不孕未育女性相比，卵巢交界性肿瘤的OR为1.5，接受治疗的已育女性与未接受治疗的不孕已育女性相比，OR为1.5。
在已育女性中，未育女性与已育女性之间卵巢交界性肿瘤风险的差异无统计学意义。未接受医学治疗的不孕未育女性发生卵巢交界性肿瘤的风险是已育未育女性的两倍。与未接受治疗的不孕未育未育女性相比，接受生育药物治疗的未育女性发生卵巢交界性肿瘤的风险无统计学意义的增加，与未接受治疗的不孕已育女性相比，接受生育药物治疗的已育女性发生卵巢交界性肿瘤的风险也无统计学意义的增加。
