Gupta G K, Bianchi D W
Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts, USA.
Obstet Gynecol Clin North Am. 1997 Mar;24(1):123-42. doi: 10.1016/s0889-8545(05)70293-x.
Laboratory advances in molecular genetics have resulted in numerous clinical applications for DNA analysis. Currently, because of cost, complexity, and resource limitations, DNA analysis is not used routinely for prenatal screening, but rather is targeted towards families at risk for an inherited condition. This article discusses the types of DNA analyses that are currently performed, the possible tissue sources of DNA for prenatal diagnosis, and the indications for DNA testing in obstetric practice. Internet addresses for the most up-to-date genetic information on a specific condition are given in this article.
分子遗传学的实验室进展已带来了众多DNA分析的临床应用。目前，由于成本、复杂性和资源限制，DNA分析并非常规用于产前筛查，而是针对有遗传疾病风险的家庭。本文讨论了当前进行的DNA分析类型、产前诊断中DNA的可能组织来源以及产科实践中DNA检测的适应症。本文还给出了关于特定疾病的最新遗传信息的互联网地址。
