Izumiya H, Watanabe H
Department of Bacteriology, National Institute of Health, Japan.
Nihon Rinsho. 1997 Mar;55(3):641-5.
Some of the virulent genes of enterohemorrhagic E. coli(EHEC) are described. stx, bfpA, eaeA and ehxA encode an enterocytotoxin homologous to Shiga toxin, bundle-forming pilus, intimin and an RTX toxin, respectively. In pathogenesis, although bfp and eae cause diarrhea, and ehx and stx seem to cause hemorrhagic colitis and hemolytic uremic syndrome, many problems remain for prevention and treatment of these symptoms. In evolution, it is intriguining that the virulent genes of EHEC might be mediated by phages, plasmids and so on, because stx is derived from a bacterio-phage, bfpA is located in a plasmid in enteropathogenic E. coli(EPEC) though it has not yet been cloned in EHEC, eaeA is one of the genes in LEE(locus of enterocyte effacement), a putative genetic cassette ubiquitous for EPEC and EHEC, and ehxA is in a plasmid.
本文描述了肠出血性大肠杆菌（EHEC）的一些毒力基因。stx、bfpA、eaeA和ehxA分别编码一种与志贺毒素同源的肠毒素、束状菌毛、紧密黏附素和一种RTX毒素。在发病机制方面，尽管bfp和eae会导致腹泻，而ehx和stx似乎会导致出血性结肠炎和溶血尿毒综合征，但在预防和治疗这些症状方面仍存在许多问题。在进化过程中，有趣的是EHEC的毒力基因可能由噬菌体、质粒等介导，因为stx来源于一种噬菌体，bfpA位于肠致病性大肠杆菌（EPEC）的质粒中，尽管它尚未在EHEC中克隆，eaeA是LEE（肠上皮细胞损伤位点）中的基因之一，LEE是EPEC和EHEC中普遍存在的一种假定基因盒，而ehxA位于质粒中。
