Kurata C, Morita K, Takaoka N, Kubota C, Takahashi Y, Yoshida Y, Yoshioka A, Okamoto Y, Nakano H
Section of Clinical Laboratory, Nara Medical University, Kashihara.
Rinsho Byori. 1997 Mar;45(3):282-5.
Wilson-Mikity syndrome, a chronic respiratory insufficiency occurring in premature newborn infants, is known to show an elevation of serum IgM, but its etiology is obscure. We studied the immunological properties of IgM in a female infant of this syndrome, whose IgM in cord blood was very high level at 639.1 mg/dl with monoclonal elevation. The IgM bound to protein(s) in human umbilical venous endothelial cells and in human lung tissue. However, IgMs from this patient after recovery, from patient's mother and from another normal newborn did not bind to the proteins. Tissue-binding activity of the patient's IgM may be associated with tissue damages in this syndrome.
威尔逊-米基蒂综合征是一种发生于早产新生儿的慢性呼吸功能不全疾病，已知其血清IgM水平会升高，但其病因尚不清楚。我们研究了一名患有该综合征女婴的IgM免疫特性，其脐带血中IgM水平非常高，达639.1mg/dl，呈单克隆升高。该IgM与人脐静脉内皮细胞和人肺组织中的蛋白质结合。然而，该患者康复后的IgM、患者母亲的IgM以及另一名正常新生儿的IgM均未与这些蛋白质结合。该患者IgM的组织结合活性可能与该综合征中的组织损伤有关。
