Fujimura M, Takeuchi T, Kitajima H, Nakayama M
Department of Neonatal Medicine, Osaka Medical Centre, Japan.
Arch Dis Child. 1989 Oct;64(10 Spec No):1379-83. doi: 10.1136/adc.64.10_spec_no.1379.
A total of 753 infants weighing less than 1800 g at birth were studied prospectively and their serum IgM concentrations measured within 72 hours of age. Placentas from 584 of these infants were examined histologically for chorioamnionitis. The results were correlated with chronic respiratory insufficiency. Altogether 101 infants developed chronic respiratory insufficiency of which 22 had bronchopulmonary dysplasia and 35 Wilson-Mikity syndrome. The remaining 44 infants were classified as 'unexplained chronic lung disease'. Mean serum IgM concentration for Wilson-Mikity syndrome was 1.02 g/l whereas it was 0.14 g/l for bronchopulmonary dysplasia and 0.32 g/l for unexplained chronic lung disease. The incidence of chorioamnionitis was significantly higher in Wilson-Mikity syndrome (30/35) compared with bronchopulmonary dysplasia (4/16) and with infants without chronic respiratory insufficiency (145/490). Wilson-Mikity syndrome was shown to be significantly correlated with the evidences of intrauterine inflammation.
对753例出生时体重小于1800g的婴儿进行了前瞻性研究，并在其出生72小时内测定血清IgM浓度。对其中584例婴儿的胎盘进行了组织学检查以诊断绒毛膜羊膜炎。将结果与慢性呼吸功能不全进行关联分析。共有101例婴儿发生慢性呼吸功能不全，其中22例患有支气管肺发育不良，35例患有威尔逊-米基蒂综合征。其余44例婴儿被归类为“不明原因的慢性肺病”。威尔逊-米基蒂综合征的平均血清IgM浓度为1.02g/L，而支气管肺发育不良为0.14g/L，不明原因的慢性肺病为0.32g/L。与支气管肺发育不良（4/16）和无慢性呼吸功能不全的婴儿（145/490）相比，威尔逊-米基蒂综合征中绒毛膜羊膜炎的发生率显著更高（30/35）。结果表明，威尔逊-米基蒂综合征与宫内炎症证据显著相关。
