致病性金黄色葡萄球菌中的磷壁酸
Teichoic acids in pathogenic Staphylococcus aureus.
作者信息
Nagel J G, Sheagren J N, Tuazon C U, Cardella T A
出版信息
J Clin Microbiol. 1977 Sep;6(3):233-7. doi: 10.1128/jcm.6.3.233-237.1977.
Abstract
Twenty-six strains of Staphylococcus aureus obtained from patients with endocarditis were studied for the production of alpha- and/or beta-ribitol teichoic acid (TA), using highly specific anti-TA antibodies prepared in rabbits. A counterimmunoelectrophoretic assay was used. Beta-TA was the predominant residue produced by all strains; alpha-TA was found in all strains, but in smaller amounts and with much strain-to-strain variations. Antibodies in patients' sera were found against beta-TA in higher titers and for longer periods than were anti-alpha-TA antibodies. Antibodies against one or both TA residues were present in all but one of 26 patients.
摘要
利用在兔体内制备的高度特异性抗壁磷壁酸（TA）抗体，对从心内膜炎患者中分离出的26株金黄色葡萄球菌进行了α-和/或β-核糖醇壁磷壁酸（TA）产生情况的研究。采用了对流免疫电泳分析法。β-TA是所有菌株产生的主要成分；所有菌株均发现有α-TA，但含量较少且菌株间差异很大。患者血清中针对β-TA的抗体效价比抗α-TA抗体更高，且持续时间更长。26例患者中除1例之外，其余患者的血清中均存在针对一种或两种TA成分的抗体。
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