Ayzenberg Ilya, Obermann Mark, Leineweber Kirsten, Franke Leonora, Yoon Min-Suk, Diener Hans-Christoph, Katsarava Zaza
Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, Essen 45122, Germany.
J Headache Pain. 2008 Apr;9(2):109-12. doi: 10.1007/s10194-008-0019-9. Epub 2008 Mar 11.
We investigated the effect of chronic administration of different pain medications on the activity of the serotonin transporter (SERT) in patients with medication overuse headache (MOH). We measured the kinetic of platelet 5-HT uptake (maximal velocity, Vmax and the Michaelis-Menten constant, Km in patients with overuse of triptans (tMOH, n = 15) or analgesics (aMOH, n = 14) before and after drug withdrawal, as well as in headache-free healthy subjects (n = 15) and patients with episodic migraine (EM, n = 16). Vmax was increased similarly in both, tMOH and aMOH compared to healthy subjects and patients with EM and normalized after withdrawal in parallel to the improvement of headache frequency. Average Km was similar in all groups at baseline and not affected by the withdrawal. The data demonstrate a transient increase of SERT activity in patients with analgesic and triptan induced MOH but do not allow to differentiate whether the increase of serotonin uptake is caused by regular intake of analgesics or triptans or is a consequence of frequent headache attacks.
我们研究了长期服用不同止痛药物对药物过量使用性头痛（MOH）患者血清素转运体（SERT）活性的影响。我们测量了曲坦类药物过度使用患者（tMOH，n = 15）或镇痛药过度使用患者（aMOH，n = 14）在停药前后以及无头痛的健康受试者（n = 15）和发作性偏头痛患者（EM，n = 16）的血小板5-羟色胺摄取动力学（最大速度，Vmax和米氏常数，Km）。与健康受试者和EM患者相比，tMOH和aMOH患者的Vmax均有类似增加，停药后随着头痛频率的改善而恢复正常。所有组的平均Km在基线时相似，且不受停药影响。数据表明，镇痛药和曲坦类药物所致MOH患者的SERT活性短暂增加，但无法区分血清素摄取增加是由定期服用镇痛药或曲坦类药物引起，还是频繁头痛发作的结果。
