Wongsrichanalai C, Nguyen T D, Trieu N T, Wimonwattrawatee T, Sookto P, Heppner D G, Kawamoto F
Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand.
Acta Trop. 1997 Feb;63(2-3):151-8. doi: 10.1016/s0001-706x(96)00618-3.
We performed in vitro drug susceptibility assays of ten Plasmodium falciparum isolates collected from Vict Nam in 1995. All isolates were found to be highly sensitive to artesunate, dihydro-artemisinin and artemisinin. They were also sensitive to quinine. All of them were resistant to chloroquine and mefloquine in vitro. This study provides the baseline estimates of in vitro susceptibility levels of the Vietnamese isolates to artermisinin and their derivatives because the data were collected soon after these drugs were introduced countrywide. It also describes some quantitative profiles of the in vitro response of other standard antimalarial drugs in Viet Nam, which is presently limited.
我们对1995年从越南收集的10株恶性疟原虫分离株进行了体外药敏试验。发现所有分离株对青蒿琥酯、双氢青蒿素和青蒿素高度敏感。它们对奎宁也敏感。所有分离株在体外对氯喹和甲氟喹耐药。本研究提供了越南分离株对青蒿素及其衍生物体外药敏水平的基线估计，因为这些数据是在这些药物在全国推广后不久收集的。它还描述了越南目前有限的其他标准抗疟药物体外反应的一些定量特征。
