Bustos M D, Saul A, Salazar N P, Gomes M
Research Institute for Tropical Medicine, Department of Health, Alabang, Muntinlupa, Metro Manila, Philippines.
Acta Trop. 1997 Mar;63(4):195-207. doi: 10.1016/s0001-706x(96)00621-3.
A malaria study area in the Philippines is described. It consists of the municipality of Morong, Bataan on the Island of Luzon. In January 1992, the population was 19454 in 106 villages located on a narrow coastal plain, or in valleys of streams running from the mountainous interior. This is an area of low level but persistent seasonal transmission of malaria with approximately one thousand cases reported each year, mainly from February to July. In spite of the low level of malaria, it is apparently quite stable. The study site has been used to investigate parameters leading to stable malaria. Hypotheses tested were that there was substantial under reporting of cases; that there was strain specific immunity stabilising the incidence of malaria and that malaria transmission in this area is highly localised in small regions with a high enough malaria prevalence to account for the year to year stability. The study plan included cross sectional surveys of parasite prevalence and seropositivity, longitudinal surveys, passive case detection, entomological surveys, anthropological surveys to assess knowledge of malaria and documentation of the health-seeking behaviour of the population.
本文描述了菲律宾的一个疟疾研究区域。该区域位于吕宋岛巴丹省的莫龙市。1992年1月，位于狭窄沿海平原或从内陆山区流出的溪流谷地中的106个村庄，人口为19454人。这是一个疟疾传播水平较低但持续存在季节性传播的地区，每年报告约1000例病例，主要集中在2月至7月。尽管疟疾水平较低，但显然相当稳定。该研究地点已被用于调查导致疟疾稳定的参数。所检验的假设是：病例报告存在大量漏报；存在特定菌株免疫力使疟疾发病率稳定；该地区的疟疾传播高度集中在疟疾流行率足够高的小区域，以解释逐年的稳定性。研究计划包括寄生虫患病率和血清阳性率的横断面调查、纵向调查、被动病例检测、昆虫学调查、评估疟疾知识的人类学调查以及记录人群的就医行为。
