Federman E B, Costello E J, Angold A, Farmer E M, Erkanli A
Health and Social Policy Division, Research Triangle Institute, Research Triangle Park, NC 27709-2194, USA.
Drug Alcohol Depend. 1997 Mar 14;44(2-3):69-78. doi: 10.1016/s0376-8716(96)01317-8.
The progression of substance use and the patterns of comorbidity of substance use and psychiatric disorders are explored prospectively in young adolescents enrolled in the Great Smoky Mountains Study. This study is an epidemiologic study of white and American Indian youths living in rural Southern Appalachia. Results from this study indicate that alcohol use without permission predicts subsequent use of illicit drugs and regular tobacco use. Use of tobacco was not associated with either later alcohol or drug use. Patterns of comorbidity showed strong cross-sectional relationships between substance use and behavioral disorders, but not emotional disorders. Use of alcohol was also associated with psychiatric diagnosis at a later interview. There were some differences between white and American Indian youths in the pattern of comorbidity of tobacco use and psychiatric disorder and the relationship between prior psychiatric disorder and later alcohol use. These findings suggest that alcohol use without permission may be an important marker for youths who are at risk for illicit drug use and/or psychiatric diagnoses.
在参与大烟山研究的青少年中，对物质使用的进展以及物质使用与精神障碍的共病模式进行了前瞻性探究。这项研究是一项针对生活在阿巴拉契亚山脉南部农村地区的白人和美国印第安青年的流行病学研究。该研究结果表明，未经许可饮酒可预测随后的非法药物使用和常规烟草使用。烟草使用与后来的酒精或药物使用均无关联。共病模式显示，物质使用与行为障碍之间存在很强的横断面关系，但与情绪障碍无关。饮酒在后来的访谈中也与精神疾病诊断相关。在烟草使用与精神障碍的共病模式以及先前精神障碍与后来酒精使用之间的关系方面，白人和美国印第安青年存在一些差异。这些发现表明，未经许可饮酒可能是有非法药物使用风险和/或精神疾病诊断风险的青少年的一个重要标志。
