Austad S N
University of Idaho, Department of Biological Sciences, Moscow 83844-3051, USA.
Exp Gerontol. 1997 Jan-Apr;32(1-2):55-63. doi: 10.1016/s0531-5565(96)00033-2.
Animals used in aging research are generally of three genetic types-outbred, inbred, and hybrid. These three types have differing uses and characteristics. Outbred animals are heterozygous at many genetic loci and all individuals are genetically unique. Inbred animals are homozygous at all loci and genetically identical to one another. F1 hybrids are heterozygous at many loci, but genetically identical. Both theoretical and empirical findings suggest that each of these models behaves somewhat differently with respect to aging. This presentation will detail these theoretical and empirical findings, and suggest what uses each genetic type might best be put to with respect to aging research.
用于衰老研究的动物通常有三种基因类型——远交群、近交系和杂交种。这三种类型有不同的用途和特征。远交群动物在许多基因位点是杂合的，所有个体在基因上都是独特的。近交系动物在所有位点都是纯合的，并且彼此基因相同。F1杂交种在许多位点是杂合的，但基因相同。理论和实证研究结果都表明，这些模型在衰老方面的表现有所不同。本报告将详细介绍这些理论和实证研究结果，并就每种基因类型在衰老研究中最适合的用途提出建议。
