Omdahl J L, DeLuca H F
J Nutr. 1977 Nov;107(11):1975-80. doi: 10.1093/jn/107.11.1975.
Vitamin D-depleted chicks which were repleted with 25-hydroxycholecalciferol adapted to the feeding of a low or high calcium diet by respectively increasing or decreasing their rate of intestinal calcium absorption. The synthesis of 1,25-dihydroxycholecalciferol in chicks fed differing calcium diets correlated directly with intestinal calcium absorption activity, suggesting that the intestinal calcium adaptation response is mediated by the modulation of kidney 25-hydroxycholecalciferol-1-hydroxylase activity. This view was strongly supported by the demonstration that repletion of the chicks with 1,25-dihydroxycholecalciferol eliminated the ability of the chicks to adjust their rates of intestinal calcium absorption to dietary levels of calcium.
用25-羟胆钙化醇补充维生素D缺乏的雏鸡，通过分别提高或降低肠道钙吸收速率来适应低钙或高钙饮食的喂养。在喂食不同钙饮食的雏鸡中，1,25-二羟胆钙化醇的合成与肠道钙吸收活性直接相关，这表明肠道钙适应性反应是由肾脏25-羟胆钙化醇-1-羟化酶活性的调节介导的。用1,25-二羟胆钙化醇补充雏鸡后，雏鸡失去了根据饮食钙水平调整肠道钙吸收速率的能力，这一证明有力地支持了这一观点。
