Eriksson H, Tornqvist H
Department of Pediatrics, University of Lund, Sweden.
Mol Cell Biochem. 1997 Apr;169(1-2):37-42. doi: 10.1023/a:1006886509892.
Growth hormone (GH) exerts acute insulin-like effects, such as increased lipogenesis and inhibition of catecholamine-induced lipolysis, in rat adipocytes that have not been exposed to GH during the preceding three hours. We found that OPC3911, a highly specific inhibitor of the cGMP-inhibited cAMP phosphodiesterase, completely blocked the antilipolytic but not the lipogenic effect of GH. This indicates that the antilipolytic effect of GH is mediated through activation of this phosphodiesterase leading to reduction of cAMP levels in the same manner as has been shown for insulin.
生长激素（GH）在过去三小时内未接触过GH的大鼠脂肪细胞中发挥急性胰岛素样作用，如增加脂肪生成和抑制儿茶酚胺诱导的脂肪分解。我们发现，OPC3911，一种cGMP抑制的cAMP磷酸二酯酶的高度特异性抑制剂，完全阻断了GH的抗脂解作用，但未阻断其脂肪生成作用。这表明GH的抗脂解作用是通过激活这种磷酸二酯酶介导的，导致cAMP水平降低，其方式与胰岛素相同。
