Fallgatter A J, Strik W K
Department of Psychiatry, University Hospital Würzburg, Germany.
Neurosci Lett. 1997 Feb 21;223(2):89-92. doi: 10.1016/s0304-3940(97)13416-4.
Near-infrared spectroscopy (NIRS) is a non-invasive optical technique which has been successfully used to register substantial cerebral ischemia. There are indications that NIRS is sensible enough to detect also small metabolic changes during the performance of cognitive tasks. In the present study, two-channel NIRS of left and right anterior frontal brain areas was applied to investigate brain oxygenation of 10 healthy subjects carrying out the continuous performance test (CPT). Significant differences between the left and right hemisphere were found. These consisted of different changes in deoxyhaemoglobin (HHB), but not in oxyhaemoglobin (O2HB) in right frontal brain areas compared to baseline during the test. Despite of some methodological restrictions, the findings suggest that the sensitivity of the NIRS-method is sufficient to detect brain oxygenation changes during cognitive activation. Furthermore, the results support the view that execution of the CPT is associated with prevalently right frontal activation.
近红外光谱技术（NIRS）是一种非侵入性光学技术，已成功用于记录严重的脑缺血情况。有迹象表明，NIRS足够灵敏，能够检测出认知任务执行过程中的微小代谢变化。在本研究中，应用左右前额脑区的双通道NIRS来研究10名进行持续操作测试（CPT）的健康受试者的脑氧合情况。发现左右半球之间存在显著差异。这些差异包括右前额脑区脱氧血红蛋白（HHB）与测试期间基线相比有不同变化，但氧合血红蛋白（O2HB）没有变化。尽管存在一些方法上的限制，但研究结果表明，NIRS方法的灵敏度足以检测认知激活过程中的脑氧合变化。此外，结果支持这样一种观点，即CPT的执行主要与右前额激活有关。
