Smith A L, Cochran A M, Mowat A P, Eddleston A L, Williams R
J Pediatr. 1977 Oct;91(4):584-9. doi: 10.1016/s0022-3476(77)80507-6.
A test of lymphocyte cytotoxicity for isolated adult rabbit hepatocytes has been performed using lymphocytes from 40 children with acute or chronic liver disease. Positive cytotoxicity was not observed in 26 children without liver disease and rarely in 13 children with disease affecting primarily the biliary tract. Temporarily positive tests were found in those with acute hepatocellular disease, but tests remained positive in patients with chronic active hepatitis, while liver function tests remained abnormal. Persistently positive test occurred in those with liver disease associated with alpha-antitrypsin deficiency. Such altered immunoresponsiveness could be an important pathogenic mechanism leading to chronic liver disease in childhood.
利用40名患有急慢性肝病儿童的淋巴细胞，对分离出的成年兔肝细胞进行了淋巴细胞细胞毒性试验。26名无肝病儿童未观察到阳性细胞毒性，13名主要影响胆道的疾病儿童也很少出现阳性。急性肝细胞疾病患者出现暂时阳性试验，但慢性活动性肝炎患者的试验仍为阳性，而肝功能试验仍异常。与α-抗胰蛋白酶缺乏相关的肝病患者出现持续阳性试验。这种改变的免疫反应可能是导致儿童慢性肝病的重要致病机制。
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