Facchini A, Stefanini G F, Bernardi M, Miglio F, Gasbarrini G, Labö G
Gut. 1978 Mar;19(3):189-93. doi: 10.1136/gut.19.3.189.
We have studied the cytotoxicity against rabbit liver cells of lymphocytes from the peripheral blood of 71 patients with various liver diseases. The group with chronic active hepatitis and three patients with acute alcoholic hepatitis showed significantly higher mean values of lymphocytotoxicity (P less than 0.001) compared with the other patients with chronic persistent hepatitis, post-necrotic fibrosis and cirrhosis. Wilson's disease, and prolonged viral hepatitis. The mean cytotoxicity of these last groups did not differ significantly from controls. In four out of six patients with chronic active hepatitis a significant decrease of lymphocytotoxicity was found after immunosuppressive therapy with oral prednisolone. A good correlation between the lymphocytotoxicity test and histological signs of activity suggests that a cell-mediated immune aggression is present in this disease.
我们研究了71例患有各种肝脏疾病患者外周血淋巴细胞对兔肝细胞的细胞毒性。与其他慢性持续性肝炎、坏死后纤维化和肝硬化、威尔逊病以及迁延性病毒性肝炎患者相比，慢性活动性肝炎组和3例急性酒精性肝炎患者的淋巴细胞毒性平均值显著更高（P小于0.001）。最后这些组的平均细胞毒性与对照组相比无显著差异。在6例慢性活动性肝炎患者中的4例，口服泼尼松龙进行免疫抑制治疗后，淋巴细胞毒性显著降低。淋巴细胞毒性试验与活动的组织学征象之间具有良好的相关性，提示该病存在细胞介导的免疫攻击。
