Albrecht P, Ennis F A, Saltzman E J, Krugman S
J Pediatr. 1977 Nov;91(5):715-8. doi: 10.1016/s0022-3476(77)81021-4.
A serologic study was made in 34 children immunized against measles at the age of 12 months. Using a sensitive virus neutralization test, it was found that many of the children had pre-existing maternal antibody to measles virus. Children with high pre-existing antibody titers failed to seroconvert. Children with lower pre-existing antibody titers seroconverted, but the resulting antibody titer was significantly lower than in children without pre-existing antibody titer. The results of this study demonstrate a probably mechanism for measles vaccine failure in 12-month-old children and support the recommendation of the Public Health Service Advisory Committee on Immunization Practices to postpone measles vaccination to 15 months of age.
对34名12个月大时接种麻疹疫苗的儿童进行了血清学研究。通过使用灵敏的病毒中和试验发现，许多儿童已有针对麻疹病毒的母体抗体。已有高抗体滴度的儿童未能发生血清转化。已有较低抗体滴度的儿童发生了血清转化，但产生的抗体滴度明显低于没有已有抗体滴度的儿童。这项研究的结果表明了12个月大儿童麻疹疫苗接种失败的一种可能机制，并支持公共卫生服务免疫实践咨询委员会将麻疹疫苗接种推迟到15个月大的建议。
