• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

捷克共和国奥洛穆茨地区人群中麻疹抗体的血清流行率——四个实验室结果的比较

Seroprevalence of Measles Antibodies in the Population of the Olomouc Region, Czech Republic-Comparison of the Results of Four Laboratories.

作者信息

Krupka Michal, Matusu Tereza, Sutova Helena, Wezdenkova Katerina, Vecerova Renata, Smesna Yvona, Kolar Milan, Frankova Hana Bilkova, Krivankova Jana, Jorenek Miroslav, Novak Zdenek, Raska Milan, Holy Ondrej

机构信息

Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 775 15 Olomouc, Czech Republic.

Mikrochem Laboratories a.s., 779 00 Olomouc, Czech Republic.

出版信息

Vaccines (Basel). 2022 Jan 25;10(2):185. doi: 10.3390/vaccines10020185.

DOI:10.3390/vaccines10020185
PMID:35214643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8880731/
Abstract

OBJECTIVES

Although the incidence of measles has decreased globally since the introduction of regular vaccination, its frequency has increased again in recent years. The study is focused on data from the Olomouc Region in the Czech Republic analyzed in four laboratories. The obtained results were compared with already published data.

METHODS

The data were provided by individual laboratories in an anonymized form-age at the time of the examination, sex, and result of test. Samples were collected between June 2018 and September 2019 and evaluated on the scale positive-borderline-negative.

RESULTS

A total of 7962 sera samples were evaluated using three different methods-two types of ELISA tests and CLIA. Positive result was issued in a total of 62.6 percent of samples, but the results of individual laboratories varied widely from 55.5 to 70.8 percent. However, the same trend with the highest levels of antibodies in people born before beginning of vaccination was observed.

CONCLUSIONS

Data show significantly different results depending on the individual laboratories and the detection kits used. The underestimation of the proportion of positive results can cause problems in selecting individuals for revaccination with a live vaccine, which may fail in weakly positive individuals.

摘要

目的

尽管自常规疫苗接种引入以来，全球麻疹发病率有所下降，但近年来其发病频率再次上升。本研究聚焦于捷克共和国奥洛穆茨地区在四个实验室分析的数据，并将所得结果与已发表的数据进行比较。

方法

数据由各个实验室以匿名形式提供——检查时的年龄、性别和检测结果。样本于2018年6月至2019年9月期间采集，并按照阳性-临界-阴性标准进行评估。

结果

共使用三种不同方法——两种酶联免疫吸附测定（ELISA）试验和化学发光免疫分析（CLIA）对7962份血清样本进行了评估。总共62.6%的样本检测结果呈阳性，但各个实验室的结果差异很大，从55.5%到70.8%不等。然而，观察到相同的趋势，即在疫苗接种开始前出生的人群中抗体水平最高。

结论

数据显示，根据各个实验室和所使用的检测试剂盒不同，结果存在显著差异。阳性结果比例的低估可能会在选择进行活疫苗再接种的个体时引发问题，因为弱阳性个体接种可能会失败。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/5d8013a2b837/vaccines-10-00185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/4eebe22d1a0b/vaccines-10-00185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/304160d24135/vaccines-10-00185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/65cddf6cd7fd/vaccines-10-00185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/e7c31ab320de/vaccines-10-00185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/580f03fc5976/vaccines-10-00185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/5d8013a2b837/vaccines-10-00185-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/4eebe22d1a0b/vaccines-10-00185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/304160d24135/vaccines-10-00185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/65cddf6cd7fd/vaccines-10-00185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/e7c31ab320de/vaccines-10-00185-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/580f03fc5976/vaccines-10-00185-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51df/8880731/5d8013a2b837/vaccines-10-00185-g006.jpg

相似文献

1
Seroprevalence of Measles Antibodies in the Population of the Olomouc Region, Czech Republic-Comparison of the Results of Four Laboratories.捷克共和国奥洛穆茨地区人群中麻疹抗体的血清流行率——四个实验室结果的比较
Vaccines (Basel). 2022 Jan 25;10(2):185. doi: 10.3390/vaccines10020185.
2
Decreasing Seroprevalence of Measles Antibodies after Vaccination - Possible Gap in Measles Protection in Adults in the Czech Republic.接种疫苗后麻疹抗体血清阳性率下降——捷克共和国成年人麻疹保护可能存在缺口。
PLoS One. 2017 Jan 13;12(1):e0170257. doi: 10.1371/journal.pone.0170257. eCollection 2017.
3
Serological survey of measles immunity in the Czech Republic, 2013.2013年捷克共和国麻疹免疫血清学调查
Cent Eur J Public Health. 2018 Mar;26(1):22-27. doi: 10.21101/cejph.a5251.
4
Serological survey of mumps antibodies in adults in the Czech Republic and the need for changes to the vaccination strategy.捷克共和国成年人腮腺炎抗体的血清学调查及疫苗接种策略的改变需求。
Hum Vaccin Immunother. 2018 Apr 3;14(4):887-893. doi: 10.1080/21645515.2017.1412021. Epub 2018 Jan 16.
5
Seroprevalence of IgG antibodies against measles in health care workers of the Strakonice Hospital.斯特拉霍尼采医院医护人员中抗麻疹IgG抗体的血清阳性率。
Epidemiol Mikrobiol Imunol. 2020 Summer;69(3):121-126.
6
Evaluation of Diagnostic Accuracy of Eight Commercial Assays for the Detection of Measles Virus-Specific IgM Antibodies.评价 8 种用于检测麻疹病毒特异性 IgM 抗体的商业检测试剂盒的诊断准确性。
J Clin Microbiol. 2021 May 19;59(6). doi: 10.1128/JCM.03161-20.
7
Measles immunity in a Czech tertiary care hospital.捷克三级护理医院的麻疹免疫力。
Vaccine. 2020 Mar 23;38(14):2889-2892. doi: 10.1016/j.vaccine.2020.02.067. Epub 2020 Feb 29.
8
[The benefit from mumps virus IgG antibody avidity testing in the population with high vaccine coverage in the context of other serological methods for laboratory diagnosis of mumps and the current epidemiological].[在腮腺炎实验室诊断的其他血清学方法及当前流行病学背景下，腮腺炎病毒IgG抗体亲和力检测在疫苗高接种覆盖率人群中的益处]
Epidemiol Mikrobiol Imunol. 2016 Winter;65(1):39-44.
9
Protection against tetanus in the aged people in the Czech Republic--cross-sectional study.捷克共和国老年人破伤风预防情况——横断面研究
Arch Gerontol Geriatr. 2005 Mar-Apr;40(2):123-8. doi: 10.1016/j.archger.2004.07.002.
10
Measles epidemics and seroepidemiology of population in Wujin, Changzhou city, Jiangsu province, China 2015.2015年中国江苏省常州市武进区麻疹疫情及人群血清流行病学调查
Vaccine. 2017 May 19;35(22):2925-2929. doi: 10.1016/j.vaccine.2017.04.018. Epub 2017 Apr 19.

引用本文的文献

1
Demographical, clinical, and complication differences between vaccinated and unvaccinated hospitalized children with measles in mogadishu somalia: a hospital-based retrospective cohort study.索马里摩加迪沙麻疹住院儿童中接种疫苗与未接种疫苗者的人口统计学、临床及并发症差异：一项基于医院的回顾性队列研究
Ann Med Surg (Lond). 2023 Apr 15;85(5):1550-1555. doi: 10.1097/MS9.0000000000000672. eCollection 2023 May.
2
Disease Progression, Clinical Features, and Risk Factors for Pneumonia in Unvaccinated Children and Adolescents with Measles: A Re-Emerging Disease in Romania.未接种麻疹疫苗的儿童和青少年麻疹患者的疾病进展、临床特征和肺炎风险因素：罗马尼亚再现的疾病。
Int J Environ Res Public Health. 2022 Oct 13;19(20):13165. doi: 10.3390/ijerph192013165.

本文引用的文献

1
Seroprevalence of IgG antibodies against measles in health care workers of the Strakonice Hospital.斯特拉霍尼采医院医护人员中抗麻疹IgG抗体的血清阳性率。
Epidemiol Mikrobiol Imunol. 2020 Summer;69(3):121-126.
2
A Serosurvey Identifying Vulnerability to Measles in Health Care Workers. A Hospital-Based Prospective Seroprevalence Study.一项针对医护人员麻疹易感性的血清学调查。一项基于医院的前瞻性血清流行率研究。
Int J Environ Res Public Health. 2020 Jun 12;17(12):4219. doi: 10.3390/ijerph17124219.
3
The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines.
预先存在的抗体对活病毒疫苗的影响。
Viruses. 2020 May 8;12(5):520. doi: 10.3390/v12050520.
4
Qualitative Variation among Commercial Immunoassays for Detection of Measles-Specific IgG.用于检测麻疹特异性IgG的商用免疫测定法之间的定性差异。
J Clin Microbiol. 2020 May 26;58(6). doi: 10.1128/JCM.00265-20.
5
Measles immunity in a Czech tertiary care hospital.捷克三级护理医院的麻疹免疫力。
Vaccine. 2020 Mar 23;38(14):2889-2892. doi: 10.1016/j.vaccine.2020.02.067. Epub 2020 Feb 29.
6
Measles: a disease often forgotten but not gone.麻疹：一种常被遗忘但并未消失的疾病。
Hong Kong Med J. 2018 Oct;24(5):512-520. doi: 10.12809/hkmj187470.
7
Serological survey of measles immunity in the Czech Republic, 2013.2013年捷克共和国麻疹免疫血清学调查
Cent Eur J Public Health. 2018 Mar;26(1):22-27. doi: 10.21101/cejph.a5251.
8
Measles Vaccine.麻疹疫苗
Viral Immunol. 2018 Mar;31(2):86-95. doi: 10.1089/vim.2017.0143. Epub 2017 Dec 19.
9
The basic reproduction number (R) of measles: a systematic review.麻疹基本再生数（R）：系统评价。
Lancet Infect Dis. 2017 Dec;17(12):e420-e428. doi: 10.1016/S1473-3099(17)30307-9. Epub 2017 Jul 27.
10
Measles.麻疹。
Lancet. 2017 Dec 2;390(10111):2490-2502. doi: 10.1016/S0140-6736(17)31463-0. Epub 2017 Jun 30.