Sy M S, Mori H, Liu D
Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA.
Curr Opin Oncol. 1997 Jan;9(1):108-12. doi: 10.1097/00001622-199701000-00017.
Tumor metastasis is one of the most life-threatening aspects of tumor progression in patients with cancer. One of the cell surface molecules that has been implicated to play an important role in tumor metastasis is CD44. Earlier results provide the initial optimism that CD44 isoform expression may be a marker for human cancers. However, more recent studies revealed that regulation of CD44 isoform expression is a complex and not well-understood phenomenon. Expression of CD44 in tumor cells can be regulated quantitatively by increasing the expression of one particular CD44 isoform or quantitatively by altering the expression of CD44 isoforms. Downregulation of CD44 is important in the metastasis of some tumor cells. We summarize some of the recent results on the potential of CD44 as a diagnostic or prognostic marker for patients with cancers.
肿瘤转移是癌症患者肿瘤进展中最危及生命的方面之一。在肿瘤转移中被认为发挥重要作用的细胞表面分子之一是CD44。早期结果带来了初步的乐观情绪，即CD44异构体表达可能是人类癌症的一个标志物。然而，最近的研究表明，CD44异构体表达的调控是一个复杂且尚未被充分理解的现象。肿瘤细胞中CD44的表达可以通过增加一种特定CD44异构体的表达进行定量调节，也可以通过改变CD44异构体的表达进行定量调节。CD44的下调在某些肿瘤细胞的转移中很重要。我们总结了一些关于CD44作为癌症患者诊断或预后标志物潜力的最新研究结果。
