CD44作为口腔癌诊断和预后工具的潜力。
The potential of CD44 as a diagnostic and prognostic tool in oral cancer.
作者信息
Emich Helena, Chapireau David, Hutchison Iain, Mackenzie Ian
机构信息
Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Oral and Maxillofacial Surgery Department, King's College Hospital, London, UK.
出版信息
J Oral Pathol Med. 2015 Jul;44(6):393-400. doi: 10.1111/jop.12308. Epub 2015 Jan 30.
The CD44 family of molecules exists as a wide range of isoforms ubiquitously expressed on the surface of mammalian cells. The variation in patterns of CD44 expression on cancer cells has been widely studied in relation to their behaviour, and further interest has recently arisen in CD44 as a marker of the subfraction tumour cells acting as cancer stem cells in several types of tumours. This review focuses on the patterns of CD44 expression on the stem cell fraction of oral squamous cell carcinoma and on the relationship of detectably different patterns of CD44 expression to the behaviour of tumours.
CD44分子家族以多种异构体形式存在，在哺乳动物细胞表面广泛表达。癌细胞上CD44表达模式的变化已被广泛研究，以探讨其与癌细胞行为的关系，最近，CD44作为几种肿瘤中充当癌症干细胞的亚群肿瘤细胞的标志物，引发了更多关注。本综述聚焦于口腔鳞状细胞癌干细胞部分的CD44表达模式，以及CD44表达模式的明显差异与肿瘤行为之间的关系。
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