CD46短共识重复序列III和IV增强麻疹病毒结合，但损害可溶性血凝素结合。
CD46 short consensus repeats III and IV enhance measles virus binding but impair soluble hemagglutinin binding.
作者信息
Devaux P, Buchholz C J, Schneider U, Escoffier C, Cattaneo R, Gerlier D
机构信息
Immunité et Infections Virales, IVMC, CNRS-UCBL UMR 5537, Lyon, France.
出版信息
J Virol. 1997 May;71(5):4157-60. doi: 10.1128/JVI.71.5.4157-4160.1997.
Abstract
The binding of a recombinant soluble form of the measles virus (MV) hemagglutinin (sH) to cells expressing hybrid CD46/CD4 proteins was compared to that of purified virus. For binding of both ligands, both CD46 external short consensus repeats I and II (SCR I and II) in the natural order were essential. The addition of SCR III and IV enhanced virus binding but inhibited sH binding. Accordingly, this lowered the ability of sH to compete with MV binding. Antihemagglutinin monoclonal antibodies selectively inhibited the binding of either sH or MV. Thus, sH and MV share a common binding site in SCR I and II but differ in their apparent avidity to CD46 under the influence of SCR III and IV.
摘要
将重组可溶性形式的麻疹病毒（MV）血凝素（sH）与表达杂交CD46/CD4蛋白的细胞的结合与纯化病毒的结合进行了比较。对于两种配体的结合，天然顺序的CD46外部短共有重复序列I和II（SCR I和II）都是必不可少的。添加SCR III和IV增强了病毒结合，但抑制了sH结合。因此，这降低了sH与MV结合竞争的能力。抗血凝素单克隆抗体选择性地抑制了sH或MV的结合。因此，sH和MV在SCR I和II中共享一个共同的结合位点，但在SCR III和IV的影响下，它们对CD46的表观亲和力不同。
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