αCaMKII突变小鼠新皮质中突触可塑性的年龄依赖性降低。
Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.
作者信息
Kirkwood A, Silva A, Bear M F
机构信息
Department of Neuroscience, Brown University, Providence, RI 02912, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3380-3. doi: 10.1073/pnas.94.7.3380.
Abstract
Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in alphaCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.
摘要
在缺乏α-钙/钙调蛋白依赖性蛋白激酶II（αCaMKII）的突变小鼠的视觉皮层中，对突触长时程增强（LTP）和长时程抑制（LTD）进行了研究。在成年突变体中，使用标准条件方案几乎无法诱发LTD或LTP。然而，在4至5周龄的突变体中可诱导出显著的LTD和LTP。因此，αCaMKII（-/-）小鼠皮层可塑性的降低是有条件的，相关条件是出生后的年龄。
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