Atebara N H, Brown G C, Cater J
Retina Vascular Unit, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Ophthalmology. 1995 Dec;102(12):2029-34; discussion 2034-5. doi: 10.1016/s0161-6420(95)30758-0.
To determine whether anterior chamber paracentesis and Carbogen inhalation therapy (95% oxygen, 5% carbon dioxide) produce a significant difference in final visual acuity in eyes with acute nonarteritic central retinal artery occlusion (CRAO), compared with untreated eyes.
In this retrospective study, the records of 89 consecutive patients seen at the Retina Vascular Unit of Wills Eye Hospital with acute CRAO who received either both anterior chamber paracentesis and Carbogen therapy, or neither anterior chamber paracentesis or Carbogen therapy, were reviewed. Forty patients were treated with both therapies, whereas 49 received neither modality. Visual acuities before treatment and at subsequent follow-up visits were measured. All patients seen within 24 hours of the onset of symptoms were treated, whereas most of those seen after 24 hours were not treated.
Stratified Wilcoxon analysis showed no statistically significant difference between the treated and untreated groups (P = 0.87) after adjusting for initial vision. A posthoc power analysis for the difference between two proportions showed that the study had adequate power (0.80) to detect a difference of the proportion of improved patients of 10% versus 25% between that treated and untreated groups.
The data suggest that anterior chamber paracentesis and Carbogen therapy offer little benefit for treating acute nonarteritic CRAO.
与未治疗的眼睛相比，确定前房穿刺术和吸入卡波金疗法（95%氧气，5%二氧化碳）对急性非动脉性视网膜中央动脉阻塞（CRAO）患者的最终视力是否产生显著差异。
在这项回顾性研究中，回顾了连续89例在威尔斯眼科医院视网膜血管科就诊的急性CRAO患者的记录，这些患者接受了前房穿刺术和卡波金疗法，或者既未接受前房穿刺术也未接受卡波金疗法。40例患者接受了两种治疗，而49例患者两种治疗方式均未接受。测量了治疗前及随后随访时的视力。所有在症状发作24小时内就诊的患者均接受了治疗，而大多数在24小时后就诊的患者未接受治疗。
在对初始视力进行校正后，分层威尔科克森分析显示治疗组和未治疗组之间无统计学显著差异（P = 0.87）。对两个比例之间差异的事后功效分析表明，该研究有足够的功效（0.80）来检测治疗组和未治疗组中改善患者比例分别为10%和25%时的差异。
数据表明，前房穿刺术和卡波金疗法对治疗急性非动脉性CRAO益处不大。
