乳腺大囊性病女性中乳腺癌风险与囊肿类型相关性的队列研究

Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast.

作者信息

Bruzzi P, Dogliotti L, Naldoni C, Bucchi L, Costantini M, Cicognani A, Torta M, Buzzi G F, Angeli A

机构信息

Unit of Clinical Epidemiology and Trials, National Institute for Cancer Research, Genova, Italy.

出版信息

BMJ. 1997 Mar 29;314(7085):925-8. doi: 10.1136/bmj.314.7085.925.

DOI:10.1136/bmj.314.7085.925

PMID:9099114

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2126378/

Abstract

OBJECTIVE

To assess correlation between type of breast cyst and risk of breast cancer in women with gross cystic disease of the breast.

DESIGN

Cohort study of women with breast cysts aspirated between 1983 and 1993 who were followed up until December 1994 for occurrence of breast cancer.

SETTING

Major cancer prevention centre.

SUBJECTS

802 women with aspirated breast cysts.

MAIN OUTCOME MEASURES

Type of breast cyst based on cationic content of cyst fluid: type I (potassium:sodium ratio > 1.5), type II (potassium:sodium ratio < 1.5), or mixed (both types). Subsequent occurrence and type of breast cancer.

RESULTS

After median follow up of six years (range 2-12 years) 15 cases of invasive breast cancer and two ductal carcinomas in situ were diagnosed in the cohort: 12 invasive cancers (and two carcinomas in situ) among the 417 women with type I cysts, two cancers among the 325 women with type II cysts, and one among the 60 women with mixed cysts. The incidence of breast cancer in women with type I cysts was significantly higher than that in women with type II cysts (relative risk 4.62 (95% confidence interval 1.26 to 29.7)). These results were confirmed after adjustment for several risk factors for breast cancer (relative risk 4.24 (1.12 to 27.5)).

CONCLUSIONS

The increased risk of breast cancer of women with breast cysts seems to be concentrated among women with type I breast cysts.

摘要

目的

评估乳腺大囊性病女性患者的乳腺囊肿类型与患乳腺癌风险之间的相关性。

设计

对1983年至1993年间接受囊肿抽吸术的乳腺囊肿女性进行队列研究，随访至1994年12月，观察乳腺癌的发生情况。

地点

主要癌症预防中心。

研究对象

802例接受囊肿抽吸术的乳腺囊肿女性。

主要观察指标

根据囊液阳离子含量划分的乳腺囊肿类型：I型（钾钠比>1.5）、II型（钾钠比<1.5）或混合型（两种类型均有）。后续乳腺癌的发生情况及类型。

结果

中位随访6年（范围2 - 12年）后，该队列中诊断出15例浸润性乳腺癌和2例原位导管癌：417例I型囊肿女性中有12例浸润性癌（和2例原位癌），325例II型囊肿女性中有2例癌症，60例混合型囊肿女性中有1例。I型囊肿女性的乳腺癌发病率显著高于II型囊肿女性（相对风险4.62（95%置信区间1.26至29.7））。在对几种乳腺癌风险因素进行调整后，这些结果得到证实（相对风险4.24（1.12至27.5））。