Ono M, Sakuda S, Suzuki A, Isogai A
Research Institute, Morinaga and Co., Ltd., Yokohama, Japan.
J Antibiot (Tokyo). 1997 Feb;50(2):111-8. doi: 10.7164/antibiotics.50.111.
Aflastatin A, a novel inhibitor of the production of aflatoxin by aflatoxigenic fungi, has been isolated from the solvent extract of mycelial cake of Streptomyces sp. and its molecular formula was determined as C62H115NO24. Aflastatin A completely inhibited aflatoxin production by Aspergillus parasiticus NRRL 2999 in liquid medium or on agar plate at a concentration of 0.5 microgram/ml. The mycelial growth of this fungus was not affected in the liquid medium at the same concentration, while the hyphal extension rate was reduced on the plate together with some morphological changes. The growth of the fungus was not completely inhibited even at a concentration of 100 micrograms/ml. Aflastatin A exhibits antimicrobial activity against some bacteria, yeasts and fungi as well as antitumor activity.
阿弗拉他汀A是一种由产黄曲霉毒素真菌产生黄曲霉毒素的新型抑制剂，已从链霉菌菌丝体饼的溶剂提取物中分离出来，其分子式确定为C62H115NO24。阿弗拉他汀A在液体培养基或琼脂平板中，浓度为0.5微克/毫升时，可完全抑制寄生曲霉NRRL 2999产生黄曲霉毒素。在相同浓度下，该真菌在液体培养基中的菌丝生长不受影响，而在平板上菌丝伸长率降低，并伴有一些形态变化。即使在浓度为100微克/毫升时，该真菌的生长也未被完全抑制。阿弗拉他汀A对一些细菌、酵母和真菌具有抗菌活性以及抗肿瘤活性。
