Torén K, Brisman J, Meding B
Institute of Internal Medicine, Section of Occupational Medicine, Sahlgrenska University Hospital, Goteborg, Sweden.
Am J Ind Med. 1997 May;31(5):551-3. doi: 10.1002/(sici)1097-0274(199705)31:5<551::aid-ajim8>3.0.co;2-w.
Two cases of contact allergy to methylisothiazolinones from slimicides used in pulp and paper mills are described. The first patient worked as a batcher in a paper mill, and he was in charge of pumping slimicides containing methylisothiazolinones. During pumping, the liquid often overflowed, and his clothes were wet daily with slimicides. After 3 months of work, he began to suffer from dermatitis, which improved when he was away from work. A clinical investigation confirmed the dermatitis diagnosis and a positive skin patch test to Kathon CG was found. The second patient worked as an agent for a firm marketing slimicides containing methylisothiazolinones. One of his tasks was to pump slimicides into the mills, and during such operations his clothes often got wet from slimicides. After some years of work, he began to suffer from erythema and dermatitis after contact with the slimicides. A skin patch test showed a strongly positive reaction to Kathon CG. These case reports draw the attention to the fact that employees in the pulp and paper industry handling slimicides are exposed to extraordinarily high concentrations of methylisothiazolinones and run a substantial risk of being sensitized. The report also stresses the need for improved handling routines of those strong sensitizers in the paper mills.
本文描述了两例因造纸厂使用的杀 slimicides 中的甲基异噻唑啉酮而引起接触性过敏的病例。首例患者是一家造纸厂的配料员，负责泵送含有甲基异噻唑啉酮的杀 slimicides。泵送过程中，液体经常溢出，他的衣服每天都被杀 slimicides 浸湿。工作 3 个月后，他开始患上皮炎，离开工作岗位后病情有所好转。临床调查确诊了皮炎，并发现对凯松 CG 进行皮肤斑贴试验呈阳性。第二例患者是一家销售含有甲基异噻唑啉酮的杀 slimicides 公司的代理商。他的一项任务是将杀 slimicides 泵入工厂，在此过程中，他的衣服经常被杀 slimicides 浸湿。工作几年后，他接触杀 slimicides 后开始出现红斑和皮炎。皮肤斑贴试验显示对凯松 CG 有强烈阳性反应。这些病例报告提醒人们注意，造纸行业中处理杀 slimicides 的员工接触到极高浓度的甲基异噻唑啉酮，面临着很高的致敏风险。报告还强调了改善造纸厂中这些强致敏剂处理程序的必要性。
